规律有氧运动对2型糖尿病患者内皮依赖性扩张功能的影响

Effect of regular aerobic exercise on endothelium dependent vasodilation in type 2 diabetes

目的探讨规律有氧运动对2型糖尿病患者的内皮功能的影响。方法 110例2型糖尿病患者分为运动试验组(n=58)和对照组(n=52),对照组给予单纯糖尿病常规治疗,运动试验组为糖尿病常规治疗的基础上,选择规律有氧运动锻炼(快步走、慢跑、太极拳及游泳等),比较经过6个月有氧运动锻炼后的试验组患者和对照组患者肱动脉内皮依赖性扩张(FMD)和非内皮依赖性舒张功能(NMD)的差异以及运动试验组与对照组患者自身6个月前后各指标的变化。结果经过6个月的规律有氧运动后,运动试验组患者的空腹血糖、HbA1c、体重、BMI、腰臀比和甘油三酯(TG)较有氧运动前下降(P<0.05),肱动脉FMD提高[(6.45±2.83)%vs.(5.20±2.61)%,P=0.019],肱动脉NMD没有变化[(13.78±7.30)%vs.(12.99±6.32)%,P=0.413];与对照组比较,运动试验组患者空腹血糖、HbA1c、体重、BMI和TG低于对照组(P<0.05),肱动脉FMD高于对照组[(6.45±2.83)%vs.(5.37±2.29)%,P=0.033],NMD在两组间没有统计学差异[(13.78±7.30)%vs.(12.67±7.09)%,P=0.245];未进行有氧运动锻炼的对照组在6个月前后FMD和NMD没有明显变化(P>0.05)。结论有氧运动能帮助2型糖尿病患者降低血糖水平,控制体重,对提高内皮功能有积极的影响。

Objective To investigate the effects of regular aerobic exercise on endothelial function in T2DM patients. Methods A total of 110 T2DM patients were assigned to experimental group（n=58） and control group（n=52）. The control group were received conventional therapy and the experimental group were treated with conventional therapy and regular aerobic exercises（eg, brisk walking, jogging, Tai chi and swimming）. We evaluated the effects of regular aerobic exercise（60-90 minutes） in T2DM patients for six months. Results After 6 months of aerobic exercise training, the levels of fasting blood glucose, HbA1c, body mass index（BMI）, waist-hip circumference ratio（WHR） and triglyceride declined and flow mediated dilation（FMD） increased compared with aerobic exercise in experimental group（all P0.05）. There were no significant deference in FMD, NMD, blood glucose, HbA1c, BMI, WHR and triglyceride before versus after aerobic exercise in control group（all P0.05）. Whilst experimental group had significantly lower fasting blood glucose, HbA1c, BMI and triglyceride, higher FMD[（6.45±2.83）% vs.（5.37±2.29）%, P=0.033] as compared with controls. Conclusion The aerobic exercise resulted in lower fasting blood glucose and HbA1c and reduced weight, which had a benefical effect on FMD in type 2 diabetes.