依达拉奉对肺叶切除患者血清SP-A和动脉血气的影响

Effects of Edaravone in serum surfactant protein A and arterial blood gas of patients undergoing lung cancer resection

目的探讨依达拉奉对胸腔镜肺叶切除术患者血清中肺表面活性蛋白A(SP-A)和动脉血气变化的影响。方法将40例行右侧肺叶切除术的肺癌患者随机分为对照组(C组)和依达拉奉组(E组)各20例。E组于诱导后切皮前给予依达拉奉1 mg/kg,30 min内滴完;C组给予等量生理盐水。两组均于切皮前即刻(T0)、单肺通气1 h(T1)和双肺通气后1 h(T2)时抽取动、静脉血,进行动脉血气分析,并测定静脉血血清SP-A的水平。结果两组单肺通气后血清SP-A水平均有明显的升高(P<0.05);与C组相比,E组血清SP-A水平较低(P<0.05),动脉血气也有明显的改善。结论依达拉奉可减少肺叶切除术患者血清SP-A水平,在一定程度上能够减轻术中肺部的急性损伤。

Objective To dynamically assess the implication of Edaravone in serum surfactant protein A（SP-A） concentration and the variation of arterial blood gas during one-lung ventilation（OLV）. Methods Forty ASAⅠorⅡ male patients aged 45-65 yr, with body mass index 18-26 kg/m2, without other serious organic disease, undergoing right lung cancer resection, were randomly divided into two groups（n=20 each）： group C（control group） and group E（Edaravone group）. The patients in group E were given 1 mg/kg of Edaravone（in 100 ml normal saline）, which were infused intravenously in 30 min before skin incision, group C received the same volume of normal saline.Arterial and venous blood samples were taken after the induction of Edaravone（T0）, at 1 h after OLV（T1） and 1 h after two-lung ventilation（T2）. The serum surfactant protein A（SP-A） concentration and the variation of arterial blood gas were determined respectively. Results Compared with T0, the levels of SP-A were increased significantly at T1 in both groups（P0.05）. In group E, the level of Sp-A was lower than that in group C at T1（P0.05）, and the variation of arterial blood gas was also improved. Conclusion Edaravone can reduce the level of SP-A and decrease the injury induced by OLV.