摘要妊娠期肝内胆汁淤积症（intrahepatic cholestasis of pregnancy，ICP）为妊娠中晚期特有的并发症之一，以皮肤瘙痒和胆酸高值为特征，主要由胆汁酸的毒性危及胎儿，对围生儿有严重不良影响，可导致早产、羊水胎粪污染、难以预测的胎死宫内、新生儿窒息等，增加围生儿病率及病死率、剖宫产率。
3Floreani A, Caroli D, Lazzari R, et al. Intrahepatic Cholestasis Of Pregnancy: New Insights Into Its Pathogenesis.J Matem Fetal Neonatal Med, 2013, 12(12): 1268-1269.
3Lammert F, Marschall HU, Glantz A, et al. Intrahepatic cholestasis of pregnancy: molecular pathogenesis, diagnosis and management. J Hepatol, 2000,33: 1012-1021.
4Riely CA, Bacq Y. Intrahepatic cholestasis of pregnancy. Clin Liver Dis,2004,8:167-176.
5Poupon R. Intrahepatic cholestasis of pregnancy: from bedside to bench to bedside. Liver Int,2005,25:467-468.
6Pusl T, Beuers U. Intrahepatic cholestasis of pregnancy. Orphanet J Rare Dis, 2007,2: 26.
7Glantz A, Marschall HU, Mattsson LA. Intrahepatic cholestasis of pregnancy: Relationships between bile acid levels and fetal complication rates. Hepatology, 2004,40 :467-474.
8Sepulveda WH, Gonzalez C, Cruz MA, et al. Vasoconstrictive effect of bile acids on isolated human placental chorionic veins. Eur J Obstet Gynecol Reprod Biol, 1991,42: 211-215.
9Ostrow JD. In vitro studies of bile salt toxicity. Hepatology, 1994,19 : 1538-1539.
10Rodrique CM, Marin JJ, Brites D. Bile acid patterns in meconium are influenced by cholestasis of pregnancy and not altered by ursodeoxycholic acid treatment. Gut, 1999,45 : 446-452.
