神经节苷脂在急性一氧化碳中毒早期脑保护治疗中的意义

Significance of Ganglioside in Cerebral Preventive Therapy of Acute Carbon Monoxide Poisoning in Early Period

目的探讨急性一氧化碳(CO)中毒早期使用神经节苷脂(GM-1)进行脑保护治疗对预防CO中毒后迟发性脑病(delayed encephalopathy after acute carbon monoxide poisoning,DEACMP)的意义。方法选择我院急诊科收治的急性CO中毒86例,随机分为观察组和对照组各43例。两组均在入院后即给予高压氧、改善微循环及营养神经等急性CO中毒常规治疗,观察组在上述治疗基础上给予GM-1治疗,观察比较两组住院时间、治疗效果、药物不良反应及治疗后2个月DEACMP发生率。结果观察组住院时间短于对照组,治疗显效率及总有效率高于对照组,治疗后2个月DEACMP发生率低于对照组,两组比较差异均有统计学意义(P<0.05)。治疗过程中两组均未出现药物不良反应。结论急性CO中毒早期使用GM-1进行脑保护治疗,可提高总有效率,降低DEACMP发病率,且无明显不良反应。

Objective To investigate the significance of ganglioside（GM-1）in cerebral protective therapy of delayed encephalopathy after acute carbon monoxide poisoning（ DEACMP）in early period of acute carbon monoxide（ CO）poisoning. Methods A total of 86 patients with acute CO poisoning were randomly divided into control group（n =43）and treatment group（n=43）. Conventional treatments of hyperbaric oxygen,microcirculation improvement and trophic nerve were given to the two groups,and the treatment group was added with GM-1 based on the treatments. The length of hospital stay,treatment effectiveness and drug adverse reaction in the two groups were observed,and incidence rates of DEACMP 2 weeks after treat-ments were also observed. Results In the treatment group,the length of stay was shorter,the total effective rate was higher, and incidence rate of DEACMP 2 weeks after treatments was lower than those in control group,and the differences were statis-tically significant（P﹤0. 05）. There was no drug adverse reaction during the treatments in the two groups. Conclusion Early use of GM-1 in cerebral protective therapy of acute CO poisoning can improve the total effective rate and reduce the incidence rate of DEACMP without obvious adverse reactions. .