氨氯地平联合缬沙坦对老年高血压患者内皮素-1、一氧化氮及血管弹性功能的影响

Effects of amlodipine combined with valsartan on the blood pressure,endothelin-1 and NO in elderly patients with hypertension

目的观察氨氯地平联合缬沙坦对老年高血压患者内皮素-1(ET—1)、一氧化氮(NO)及血管弹性功能的影响。方法 老年高血压患者40例随机分为2组,每组20例。观察组给予氨氯地平与缬沙坦联合治疗,对照组仅给予缬沙坦治疗,比较2组血压、ET-1、NO以及血管弹性功能指标变化。结果 2组治疗2、4、6、8周后,血压均较治疗前下降,且观察组下降较对照组更明显(P均<0.05);与治疗前比较,2组治疗8周后ET-1、NO均改善(P<0.05),且观察组改善较对照组明显(P<0.05);2组治疗8周后,大动脉弹性指数(C_1)、小动脉弹性指数(C_2)均较治疗前增高,且观察组较对照组增高明显(P<0.05);治疗8周后,2组脉搏波传导速度(PWV)及踝臂指数均优于治疗前,且观察组优于对照组(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论 氨氯地平联合缬沙坦治疗老年高血压患者降压效果明显,ET-1均明显下降,NO明显升高,血管弹性功能改善。

Objective To observe the effect of amlodipine combined with valsartan on the blood pressure,endothelin（ET-1） and NO in elderly patients with hypertension.Methods Forty cases of elderly patients with hypertension were randomly divided into two groups of 20 cases in each group.Observation group were given amlodipine and valsartan combination therapy,the control group only received valsartan,compared two groups＇ blood pressure,ET-1,NO and vascular elasticity index changes.ResuItB Two groups 2,4,6,8 weeks after treatment,compared with pre-treatment,blood pressure were dropped,and the observation group decreased more signiiicandy than in the control group（P〈0.05）;compared with before treatment,2 groups after 8 weeks of treatment,ET-1,NO were improved（P〈0.05）,and observation group significandy improved compared with the control group（P〈0.05）;in both groups after 8 weeks of treatment,arterial elastic index（C1,C2）increased than those before treatment,and observation group significandy higher than the control group（P〈0.05）;after 8weeks of treatment,in two groups pulse ware velocity（PWV） and ankle-brachial index were better than those pre-treatment,observation group was better than control group（P〈0.05）.2 groups＇ incidence of adverse reactions was showed no significant difference（P〈0.05）.Conclusion It＇s demonstrated that the amlodipine combined with valsartan had good efficacy in elderly hypertensive patients the antihypertensive effect is obvious,ET-1 were significandy decreased,NO were significandy increased,vascular elastic function were improved.