G蛋白β3亚单位基因825C/T多态性与中国人群原发性高血压相关性的Meta分析

Correlation between C825T gene polymorphism of GNB3 and essential hypertension in Chinese population:a Meta-analysis

目的系统评价G蛋白β3亚单位（GNB3）基因825C/T多态性与中国人群原发性高血压（EH）发病风险的关系。方法由两名评价者独立检索PubMed、EMbase、CNKI、CBM和WanFang数据库,收集探讨GNB3基因825C/T多态性与中国人EH相关性的病例-对照研究,检索时限均为建库至2013年9月30日。文献筛选及资料提取后,对纳入文献按NOS进行质量评价,然后采用Stata12.0软件行Meta分析。结果最终纳入30个病例-对照研究,包括EH患者5054例,对照人群5565例。Meta分析结果显示,与对照组相比,GNB3基因825C/T多态性与中国人EH发病风险间无统计学差异[TT vs.CC：（OR=1.13,95%CI：0.89～1.43,P=0.33）;TT vs.CT＋CC：（OR=1.04,95%CI：0.86～1.26,P=0.70）;CT vs.CC：（OR=1.08,95%CI：0.98～1.19,P=0.11）;TT＋CT vs.CC：（OR=1.11,95%CI：0.96～1.29,P=0.15）;T vs.C：（OR=1.06,95%CI：0.95～1.20,P=0.30）]。结论当前证据表明中国人群GNB3基因825C/T多态性与EH发病无关。

Objective To review systematically the relationship between C825T gene polymorphism of GNB3 and risk of essential hypertension （EH） in Chinese population. Methods The databases of PubMed, Embase, CNKI, CBM and WangFang Database were retrieved independently by 2 reviewers for collecting the case-control studies on correlation between C825T gene polymorphism of GNB3 and EH in Chinese population from database establish time to Sept. 2013. After literatre screening and data extracting, the included studies were given quality reviewing according to NOS and a Meta-analysis by using Stata12.0 software. Results There were 30 case-control studies included involving 5054 EH patients and 5565 control persons. The results of Meta-analysis showed that between C825T gene polymorphism of GNB3 and risk of EH had no statistical difference in Chinese population [TT vs. CC：（OR=1.13, 95%CI：0.89-1.43, P=0.33）;TT vs. CT＋CC：（OR=1.04, 95%CI：0.86-1.26, P=0.70）;CT vs. CC：（OR=1.08, 95%CI：0.98-1.19, P=0.11）;TT＋CT vs. CC：（OR=1.11, 95%CI：0.96-1.29, P=0.15）;T vs. C：（OR=1.06, 95%CI：0.95-1.20, P=0.30）]. Conclusion The current evidence indicates that C825T gene polymorphism of GNB3 is not correlated to risk of EH.