摘要
【目的】探讨白细胞介素-18(IL-18)、IL-33在支气管哮喘(简称哮喘)中表达及意义。【方法】选取125例哮喘患者(哮喘组),根据患者病情将其分为哮喘缓解48例(缓解组),急性发作期77例(急性期组),其中轻度组32例,中度组25例,重度组20例,另选取正常体检者48例(对照组),采用免疫吸附法测定各组IL-18、IL-33水平,同时观察第一秒用力呼气容积(FEV1)占预计值的百分比(FEV1%)及嗜酸性细胞(EOS)的变化。【结果】与对照组相比,哮喘组 IL-18,IL-33,EOS 水平显著升高,而 FEV1%水平显著下降,差异有统计学意义( P <0.05);与缓解组相比,急性期组IL-18,IL-33,EOS水平显著升高,而 FEV1%水平显著下降,差异有统计学意义( P <0.05);与轻、中度哮喘组相比,重度组患者 IL-18,IL-33,EOS水平较高,而 FEV1%水平较低,差异有统计学意义( P <0.05)。急性期各组患者治疗后IL-18,IL-33,EOS水平显著低于治疗前,而FEV1%,高于治疗前,差异有统计学意义( P <0.05)。【结论】IL-18、IL-33在急性哮喘发作过程中起到促炎作用,加强气道反应;对急性期患者应用激素治疗能有效抑制炎症,控制气道反应,改善患者预后。
[Objective]To explore the expressions and significance of interleukin-18(IL-18) and interleukin-33 (IL-33) in bronchial asthma(asthma) .[Methods]Totally 125 patients with asthma(asthma group) were chosen . According to the patients'condition ,all patients were divided into asthma remission group ( n=48) ,acute asthma group( n=77) ,mild asthma group(n=32) ,moderate asthma group( n=25) and severe asthma group( n=20) . Other 48 normal subjects were selected as the control group .The levels of IL-18 and IL-33 in groups were meas-ured by immunosorbent method .Meanwhile ,the changes of the percentage of forced expiratory volume in one sec-ond(FEV1) of predictive value(FEV1% ) and eosinophils(EOS) were observed .[Results]Compared with control group ,the levels of IL-18 ,IL-33 and EOS in asthma group were markedly increased ,while FEV1% was markedly decreased ,and there was significant difference( P〈0 .05) .Compared with asthma remission group ,the levels of IL-18 ,IL-33 and EOS in acute asthma group were markedly increased ,while FEV1% was markedly decreased , and there was significant difference( P 〈0 .05) .Compared with mild and moderate asthma groups ,the levels of IL-18 ,IL-33 and EOS in severe asthma group were higher ,but FEV1% was lower ,and there was significant difference( P 〈0 .05) .The levels of IL-18 ,IL-33 and EOS in groups in acute period after treatment were lower than those before treatment ,while FEV1% after treatment was higher than that before treatment ,and there was significant difference( P〈0 .05) .[Conclusion]IL-18 and IL-33 may play the proinflammatory role during acute at-tack of asthma attack ,and can strengthen airway reaction .For patients treated with hormone therapy ,IL-18 and IL-33 can effectively inhibit inflammation ,control airway reaction and promote the prognosis of patients .
出处
《医学临床研究》
CAS
2014年第4期746-748,共3页
Journal of Clinical Research