肝硬化合并低钠血症与血浆血管加压素变化关系研究

The Correlation between Hepatocirrhosis with Hyponatremia and Plasma Vasopressin

目的:测定肝硬化合并低钠血症患者血清中血管加压素(VP)水平,分析肝硬化合并低钠血症患者Child-pugh分级关系、血、尿渗透压的关系、VP关系,了解对肝硬化合并低钠血症患者诊断意义并探讨肝硬化患者低钠血症发病机制。方法:检测包括80例肝硬化腹水患者的100例肝硬化患者的肝功能、血钠、血尿渗透压、VP水平,并将低钠血症与Child-pugh分级、血、尿渗透压、VP等指标进行相关性分析。结果:本研究中,70例肝硬化腹水合并低钠血症患者体内VP含量显著高于普通肝硬化患者,并且VP含量随着病情分级加重而增高。结论:肝硬化容易并发低钠血症,并发症患者血清中血管加压素(VP)水平与肝功能Child-pugh分级、血、尿渗透压有很大关系。

Objective：This study is to determine the vasopressin（VP）levels of patients with hepatocirrhosis with hyponatremia,analysis of hepatocirrhosis with hyponatremia in patients with Child-pugh,hierarchical relationships,the relationship between blood and urine osmotic pressure,VP,understand the diagnosis significance in patients with hepatocirrhosis with hyponatremia and to explore the pathogenesis of hyponatremia in patients with cirrhosis.Methods：To test 100cases of liver cirrhosis＇ liver function,blood sodium,blood in urine osmotic pressure,VP level and hyponatremia and Child-pugh,grading,indices such as blood,urine osmotic pressure,the VP for correlation analysis.Results：In this study,70patients with liver cirrhosis ascites with hyponatremia VP level was significantly higher than that of normal liver cirrhosis patients,and heighten the VP content classification as the illness is aggravating.Conclusion：Cirrhosis of the liver easily complicated with low sodium blood sickness and complications in patients,and the degree of hyponatremia has great relationship with Child-pugh classification of liver function,blood and urine osmotic pressure.