垂体腺瘤中FRα的表达与临床意义

The expression and clinical significance of FRα in pituitary adenomas

目的检测垂体腺瘤中叶酸受体α(FRα)的表达情况,探讨FRα与垂体腺瘤相关临床指标的关系。方法运用冰冻切片免疫组化方法,检测124例垂体腺瘤中FRα的表达情况,分析其与患者性别、年龄、肿瘤径线、肿瘤侵袭性的关系。结果 FRα在NF腺瘤中的阳性率为73.8%(31/42),在PRL腺瘤中的阳性率为9.7%(3/31),在GH腺瘤中的阳性率为6.7%(2/30),在ACTH腺瘤中的阳性率为9.5%(2/21),FRα在NF腺瘤中的表达水平明显高于在其他病理类型垂体腺瘤中的表达(P<0.05)。在垂体NF腺瘤中,FRα的表达与肿瘤的侵袭性有关(P<0.05),与性别、年龄、肿瘤大小无明显关系(P>0.05)。在其他三种垂体腺瘤中,FRα与上述指标无明显关系。结论 FRα在垂体NF腺瘤中高表达,在其他病理类型的垂体腺瘤中低表达;FRα与垂体NF腺瘤的侵袭性相关。

Objective To study the expression of folate receptor at （FRa） in pituitary adenomas, and to explore its relationship with some clinical features of pituitary adenoma. Methods The expression of FRa in frozen tissue sections from 124 patients with pituitary adenomas was examined with immunohistochemical method. It was analyzed the relationship of expression level of FRa with some clinical features including gender, age, diameter and invasiveness of tumors. Results The positive rates of FRa expression in NF adenoma,PRL adenoma, GH adenoma,and ACTH adenoma were 73.8% （31/42） ,9.7% （3/31） ,6.7% （2/30） ,and 9.5% （2/21）, respectively. FRa expression level in NF adenoma was significantly higher than that in other types of pituitary adenomas（P 〈 0.05）. In NF pituitary adenoma, the expression of FRet was significantly related to tumorous invasiveness （P 〈 0.05）. The expression of FRet was not related to gender, age, and size of tumors （P 〉 O. 05 ）. In the other three types of pituitary adenomas, FRa has no relationship with these clinical features. Conclusions FRa is highly expressed in NF pituitary adenoma, lowly expressed in other types of pituitary adenomas, and is related to invasiveness of NF pituitary adcnoma.