五苓散加味治疗颅脑损伤脑水肿的临床观察

Clinical observation of treatment of traumatic brain injury Wulingsan flavored cerebral edema

目的:观察中药利水方剂五苓散治疗颅脑损伤脑水肿的临床疗效。方法:将60例颅脑损伤患者随机分成两组,治疗组和对照组各30例,对照组接受常规西药治疗,如脱水剂、止血剂、营养神经类药物等;治疗组在接受常规西药治疗的同时,给予服用五苓散加味方剂,疗程均为10d。疗程结束后分别统计并比较两组伤后第1、3、10天的疗效指标,如脑水肿情况、中线移位情况、格拉斯哥昏迷评分(GCS)、日平均尿量、电解质变化、肝肾功能及空腹血糖等。结果:治疗组第10天的脑水肿情况、中线移位情况、GCS、电解质K+、Na+等疗效指标优于对照组,且有统计学意义(P<0.05)。结论:中药利水方剂五苓散加味对颅脑损伤脑水肿的疗效确切。

Objective： To observe the therapeutic effect of one traditional Chinese medicine prescription, Supplemented Wuling San pulvis, in the treatment of brain edema caused by traumatic brain injury. Methods： 60 craniocerebral injury patients were randomly divided into two groups,one treatment group and one control group（30 in each）. Patients in the control group were administered with routine western medicine including dehydrants, hemostatics and neurotrophic drugs, while patients in the treatment group additionally accepted Supplemented Wuling San pulvis.Both groups were continuously treated for 10 days. On the 1st, 3rd and 10th day, therapeutic effect was compared according to the changes of brain edema, midline shift, Glasgow coma scores（GCSs）, daily mean urine volume, blood electrolytes, hepatic and renal function, and fasting blood glucose as well. Results： On the 10th day, the changes of cerebral edema, midline shift, GCSs, K＋ and Na＋ electrolytes in the treatment group were significantly better than those in the control group（P〈0.05）. Conclusion： The traditional Chinese medicine prescription Supplemented Wuling San pulvis can effectively treat brain edema caused by traumatic brain injury.