N-乙酰半胱氨酸对稳定期慢性阻塞性肺疾病的治疗作用

Therapeutic Effect of N-acetylcysteine on Stable Chronic Obstructive Pulmonary Disease

目的:探讨N-乙酰半胱氨酸(NAC)对稳定期慢性阻塞性肺疾病(COPD)患者的治疗效果。方法:选取本院2012年8月-2013年2月确诊为COPD稳定期的60例患者,按照随机数字表法将其分为观察组和对照组各30例。对照组给予常规治疗,观察组在常规治疗基础上联合NAC治疗1年,观察比较两组FEV1%pred、SGRQ评分、急性加重次数及住院次数的差异。结果:两组治疗后与治疗前比较,FEV1%pred明显升高(P<0.05),SGRQ评分、急性加重次数、住院次数均明显降低(P<0.05);且两组治疗后比较差异均有统计学意义(P<0.05)。结论:NAC可以显著改善稳定期COPD患者肺功能、生活质量,并降低急性加重次数、住院次数,值得临床推广。

Objective：To investigate the therapeutic effect of N-acetylcysteine（NAC） on stable chronic obstructive pulmonary disease（COPD）.Method：Sixty patients diagnosed stable COPD in our hospital from August 2012 to February 2013 were selected,they were randomly divided into the observation group and the control group, 30 cases in each group.The control group was treated with conventional therapy,and the observation group added N-acetylcysteine for 1 year on the basis of the control group.The FEV1%pred,SGRQ score,the number of acute exacerbation and hospitalization of the two groups were observed and compared.Result：Two groups were compared before and after treatment,FEV1%pred significantly increased（P〈0.05）,SGRQ score,the number of acute exacerbation and hospitalization significantly decreased（P〈0.05）,and there were significant differences after treatment between two groups（P〈0.05）.Conclusion：NAC can significantly improve pulmonary function and quality of life,reduce the number of acute exacerbation and hospitalization in stable COPD patients,is worthy of clinical promotion.