颈动脉狭窄程度与认知功能MMSE评分的相关性研究

Relevant Research of Degree of Carotid Artery Stenosis(CAS) with MMSE Score of Cognitive Function

目的:分析颈动脉狭窄程度与认知功能MMSE评分的关系。方法:回顾性分析本院2010-2012年收治的122例门诊及住院颈动脉狭窄患者的全部资料,所有患者行颈动脉多普勒超声检查后,按颈动脉狭窄程度分为三组,并行认知功能MMSE评分,研究动脉狭窄程度与认知功能MMSE评分的关系。结果:81例颈内动脉患者中,发生左侧的有38例(31.1%),右侧的有22例(18.0%),双侧的有21例(17.2%);13例颈外动脉患者中,发生左侧的有6例(4.9%),右侧的有3例(2.5%),双侧的有4例(3.3%);28例颈总动脉患者中,发生左侧的有15例(12.3%),右侧的有6例(4.9%),双侧的有7例(5.7%),结果有统计学差异(P<0.05);Ⅰ组的MMSE评分为(28.8±1.5)分,Ⅱ组为(28.2±1.4)分,Ⅲ组为(27.3±1.1)分,三组比较差异有统计学意义(P<0.05);且随着颈动脉狭窄程度的加重,MMSE评分降低,两者呈正相关(r=0.731,P<0.05)结论:颈动脉狭窄程度与认知功能MMSE评分呈正相关,颈动脉狭窄超过75%的患者应行颈动脉内膜剥脱术或颈动脉内支架成形术治疗。

Objective： To analyze the relationship of degree of CAS with MMSE score of cognitive function. Method： Data of 122 patients with CAS from inpatient department and outpatient department were retrospectively analyzed. All patients were given carotid artery Doppler ultrasound examinations and were divided into three groups according to the degree of carotid stenosis, then evaluated by MMSE scores of cognitive function. Relationship of degree of CAS with MMSE score of cognitive function was studied. Result： Among 81 patients of internal carotid artery, there were left side 38 cases（31.1%）, right side 22 cases（18.0%）, both sides 21 cases（17.2%）; among 13 patients of external carotid artery, there were left side 6 cases（4.9%）, right side 3 cases（2.5%）, both sides 4 cases（3.3%）; among 28 patients of common carotid artery, there were left side 15 cases（12.3%）, right side 6 cases（4.9%）, both sides 7 cases（5.7%）. MMSE score of the group Ⅰ was（28.8±1.5）, MMSE score of the group Ⅱ was（28.2±1.4）, MMSE score of the group Ⅲ was（27.3±1.1）, the difference was statistically significant between the three groups（P〈0.05）; This implied that the severer the degree of CAS was, the lower the MMSE score was, both were positively correlated（r=0.731, P〈0.05）. Conclusion： Degree of CAS has a positive relationship with MMSE score of cognitive function. Patients with CAS 75% should have carotid endarterectomy or carotid stent angioplasty for treatment.