他汀类药物预防心肌梗死后房颤发生的临床研究

Clinical Studies of Statins to Prevent Atrial Fibrillation after Myocardial Infarction

目的:探讨他汀类药物对心肌梗死后房颤的预防作用。方法:选取2012年1月-2013年12月本院收治的80例急性心梗患者,根据随机数字表法将其分为他汀组和非他汀组各40例。他汀组入院前已规律服用他汀类药物,非他汀组入院前未服用过他汀类药物,对两组患者进行心电监测,观察心梗后房颤的发生率及阵发性房颤再发生率。结果:他汀组的房颤发生率10.0%明显低于非他汀组的22.5%,且阵发性房颤再发生率33.3%明显低于非他汀组的66.67%,差异均有统计学意义(P<0.05)。结论:他汀类药物能有效降低MI后房颤的发生率,且有利于预防阵发性房颤的再发生,有效预防阵发性房颤发展为永久性房颤。

Objective：To investigate the preventive effect of statins on atrial fibrillation after myocardial infarction. Method：80 patients with acute myocardial infarction from January 2012 to December 2013 in our hospital were selected, they were randomly divided into the statin group and the non-statin group according to the random number table method, 40 cases in each group.The statin group was given statins regularly before admission,the non-statin group wasn＇t given statins before admission.The two groups underwent ECG monitoring,and the incidence of atrial fibrillation after myocardial infarction and the recurrent rate of paroxysmal atrial fibrillation of the two groups were observed and compared.Result： The incidence of atrial fibrillation of the statin group was 10.0%,it was significantly lower than 22.5% of the non-statin group,and the recurrence rate of paroxysmal atrial fibrillation of the statin group was 33.3%,it was significantly lower than 66.7% of the non-statin group,the differences were statistically significant（P〈0.05）.Conclusion：Statins can reduce the incidence of atrial fibrillation after MI,and conducive to the prevention of paroxysmal atrial fibrillation recur.It can effectively prevent the paroxysmal atrial fibrillation become permanent atrial fibrillation.