阿托伐他汀对慢性肾功能衰竭患者的肾脏保护作用

Effect of Atorvastatin on renal function in patients with chronic renal failure

目的:观察阿托伐他汀对慢性肾功能衰竭患者肾脏保护作用。方法:选取血脂正常的慢性肾功能衰竭患者70例,随机分为对照组和治疗组,治疗组服阿托伐他汀20 mg,1次/d,连续观察1年。观察血压(收缩压/舒张压:SBP/DBP)、血浆C-反应蛋白(CRP)、血浆总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、血肌酐(Scr)和24 h尿蛋白(U-pro)的变化。结果:1年后,治疗组患者CRP含量明显减少,24 h尿蛋白减少,同时患者血肌酐也呈下降趋势。治疗组患者肾功能得以改善,两组比较差异有统计学意义(P<0.05)。结论:阿托伐他汀可以通过抑制慢性肾功能衰竭患者微炎性反应,减少尿蛋白排出,改善肾功能。

Objective To investigate the effect of statin therapy in patients with chronic renal failure（CRF）. Method Seventy patients with chronic,renal failure patients were divided randomly into experimental group （n = 36） and control group（ n = 34 ）. Exprimeutal group received atorvastatin （20 rag/d） on the basis of conventional treatment of control group. The concentrations of serum C - reactive protein （CRP） ,trigyeerides ,total cholesterol, HDL cholesterol, LDL cholesterol ,serum ereatinine and proteinurla were detected by radioimmunoas- say before and after 12months treatment. Results After 12 months treatment, U - pro （ 1. 70 ± 0. 31 vs2. 17 ± 0. 39 ） mg/d, CRP （ 2. 58 ± 1.12vs3. 77 ± 1.49 ） mg,/L, and serum ereafinine （ 279.95 ± 46. 4vs316. 70 ± 42.20 ） μmol/L in atorvastatin group were decreased signifi- cantly compared to the exprlmeutal group（ all P 〈 0. 05 - 0. 01 ）. Conclusion In addition to its antilipidemia effect atorvastatin is shown to be a beneficial on reducing proteinuria in CRF which may be attributed to its anti - inflammatory effect of lowering plasma CRP and improve renal function.