经蝶手术治疗泌乳素型垂体腺瘤的临床效果观察

Clinical efficacy observation of transsphenoidal surgery in the treatment of prolactin pituitary adenoma

目的 探讨分析经蝶手术治疗泌乳素型垂体腺瘤的临床疗效.方法 回顾性分析在该院治疗的34例泌乳素型垂体腺瘤患者的临床记录资料.结果 治疗后,肿瘤直径小于10 mm,患者的全切率和缓解率均明显高于直径为10～30 mm的患者,也高于直径超过40mm的患者,差异具有统计学意义（P＜0.05）;非侵袭性肿瘤患者的全切率和缓解率也均明显高于侵袭肿瘤患者,差异亦有统计学意义（P＜0.05）.结论 经蝶手术治疗可有效治疗小型泌乳素型垂体腺瘤,对于直径超过10 mm的大腺瘤和巨大腺瘤来说整体效果相对不佳.

Objective To investigate clinical efficacy of transsphenoidal surgery in the treatment of pro]actin pituitary adenoma. Methods Clinical records 34 cases of patients with prolactin pituitary adenoma in our hospital were reviewed. Results After treatment, both the full cut rate and remission rate were not only higher in patients with tumor diameter less than 10 mm than in patients with tumor diameter 10 -30 mm or more than 40 ram, （ P 〈 0.05 ）, but also higher in non-invasive patients than in invasive patients （ all P 〈0.05）. Conclusion Transsphenoidal surgery can be effective for small prolactinoma, but not for prolactinoma of 10 mm or more in diameter.