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糖尿病皮肤溃疡创面修复机制的研究进展 被引量:10

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摘要 难愈性皮肤溃疡是糖尿病的严重并发症之一,目前研究发现糖尿病发生时有多种基因、分子和细胞功能受损,如生长因子、活性氧分子、miRNA、内皮祖细胞等,这些因子表达的异常共同导致了糖尿病溃疡创面的愈合不良。本文阐述了近年相关分子机制的研究进展。
出处 《中国中西医结合皮肤性病学杂志》 CAS 2014年第2期133-136,共4页 Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine
基金 上海市中医药事业发展三年行动计划重大项目(编号:ZYSNXD-CC-ZDYJ018) 上海市优秀学术带头人项目(编号:11XD1404700) 国家自然科学基金(编号:81102596) 上海市科学技术委员会科技支撑项目(编号:12401903500)
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  • 1Brem H,Tomic-Canic M.Cellular and molecular basis of wound healing in diabetes[J].J Clin Invest,2007,117:1219-1222.
  • 2Park NY,Lim Y.Short term supplementation of dietary antioxidants selectively regulates the inflammatory responses during early cutaneous wound healing in diabetic mice[J].Nutr Metab(Lond),2011,8:80.
  • 3Park NY,Park SK,Lim Y.Long-term dietary antioxidantcocktail supplementation effectively reduces renal inflammation in diabetic mice[J].Br J Nutr,2011,106:1514-1521.
  • 4Meydani M,Lipman RD,Han SN,et al.The effect of long-term dietary supplementation with antioxidants[J].Ann N Y Acad Sci,1998,854:352-360.
  • 5Lan CC,Wu CS,Huang SM,et al.High-glucose environment enhanced oxidative stress and increased interleukin-8 secretion from keratinocytes:new insights into impaired diabetic wound healing[J].Diabetes,2013,62:2530-2538.
  • 6Shin SH,Han SK,Jeong SH,et al.Potential of Oncostatin M to accelerate diabetic wound healing[J].Int Wound J,2012,11:233-238.
  • 7Ansurudeen I,Sunkari VG,Grünler J,et al.Carnosine enhances diabetic wound healing in the db/db mouse model of type 2 diabetes[J].Amino Acids,2012,43:127-134.
  • 8Barginear MF,Van Poznak C,Rosen N,et al.The heat shock protein 90 chaperone complex:an evolving therapeutic target[J].Curr Cancer Drug Targets,2008,8:522-532.
  • 9Whitesell L,Lindquist SL.HSP90 and the chaperoning of cancer[J].Nat Rev Cancer,2005,5:761-772.
  • 10Garrido C,Gurbuxani S,Ravagnan L,et al.Heat shock proteins:endogenous modulators of apoptotic cell death[J].Biochem Biophys Res Commun,2001,286:433-442.

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