慢性乙型肝炎患者HBV DNA载量与ALT水平的相关性分析

Correlation between HBV DNA load and ALT level: analysis of 800 patients with chronic hepatitis B

目的分析HBV DNA载量与ALT水平的关系,探讨HBV感染时ALT发生变化的原因。方法以ALT值作为因变量,以HBV DNA作为自变量,应用SPSS 16.0软件对指标进行曲线拟合,建立曲线回归方程后对曲线方程进行分析。结果通过软件分析建立幂模型:R2=0.107,F=85.887,P=0.000,b0=47.785,b1=0.075,b2=0。分析曲线发现随着HBV DNA载量的增加,ALT的值持续升高,但升高幅度越来越小;当HBV DNA载量达到一定范围后,随着HBV DNA载量的增加,ALT的值变化幅度极小,并无限接近某一特定值。结论 ALT的变化与HBV DNA载量有相关性,但HBV DNA可能不是导致ALT值发生变化的最直接的原因。

Objective To analyze the relationship between hepatitis B virus （HBV）DNA load and serum alanine aminotransferase （ALT） level and to investigate the reason that ALT level changes in patients with HBV infection.Methods ALT level （dependent variable）and HBV DNA load （independent variable）were subjected to curve fitting using SPSS 16.0 to establish a curve regression equation and analyze the curve regression equation.Results A power model was established by software analysis,with the following results：R^2 =0.107,F=85.887,P=0.000,b0 =47.785,b1 =0.075,b2 =0.The curve analysis showed that as the HBV DNA load increased,the ALT level kept rising,but at a decreasing rate;within a certain range,the increase in HBV DNA load led to little change in ALT level,which was infinitely close to a certain value.Conclusion ALT level is correlated with HBV DNA load,but HBV DNA may not be the most direct cause of change in ALT level.