原发性胆汁性肝硬化患者血清抗gp210抗体检测的意义

Significance of serum anti-gp210 antibody detection in diagnosis of primary biliary cirrhosis

原发性胆汁性肝硬化(PBC)是一种以肝内小胆管进行性破坏为特征,并可在一定时期内进展为肝硬化的慢性疾病。抗线粒体抗体,尤其是抗M2抗体对于诊断PBC具有很高价值,但其与PBC病情程度及预后无关,且部分患者该抗体阴性。国内外已有文献报道抗核抗体特别是抗gp210抗体,与PBC的关系密切。归纳显示,抗gp210抗体诊断PBC特异性及敏感性均较高,且对于抗M2抗体阴性的PBC有更高检测价值,另外,其对于评估PBC预后及疾病发展模式有良好的预测价值。认为抗gp210抗体具有较高的检测意义及临床价值,值得广泛推广。

Primary biliary cirrhosis （PBC）is a chronic disease characterized by progressive destruction of intrahepatic small bile ducts, which may progress to liver cirrhosis.Anti-mitochondrial antibodies,especially anti-M2 antibody,have a high diagnostic value for PBC, but they are unrelated to the severity and prognosis of the disease and are negative in some patients.There have been reports from around the world that anti-nuclear antibodies,especially anti-gp210 antibody,are closely associated with PBC.It showed that anti-gp210 antibody has high specificity and sensitivity for the diagnosis of PBC,especially for the patients with negative anti-M2 antibody tests;in addition,it has a high predictive value for the prognosis and development model of the disease.Anti -gp210 antibody has a high diagnostic value for PBC,with great clinical significance,so its detection holds promise for clinical application.