p19在颌面部皮肤血管瘤不同时期的表达

Expression of p19 in infantile dermal hemangiomas

目的:探讨p19在血管瘤发生、发展及退化过程中的表达状况及其意义。方法:采用免疫组织化学方法 (SABC法)检测人皮肤血管瘤增生期、退化期及正常皮肤组织中p19的表达水平。利用计算机图像分析技术测量不同时期血管瘤组织和正常皮肤组织p19表达的积分光密度和面积。结果:增生期血管瘤内皮细胞p19表达水平低于退化期,差异有统计学意义(P<0.05)。结论:p19的表达水平与血管瘤的发生、发展与消退有关。

Objective：To investigate the expression and significance of p19 in the occurrence,development and regression of infantile hemangiomas.Method：The expression of p19 was examined in proliferating,involuting human hemangiomas and normal skin tissues by using immunohistochemical technique.Image analysis system was applied to measure the expressing level of p19 at different stage of hemangiomas and in normal skin tissues.Result：The expression of p19 was significantly lower in proliferating hemangiomas than in involuting hemangomas （P 〈0.05）.Conclusion：The expression of p19 is associated with the occurrence,development and regression of human hemangiomas.