氨甲苯酸联合维生素E治疗宫内节育器致子宫异常出血的疗效观察

Clinical Curative Observation on the Effects of Combined Treatment with Aminomethylbenzoic Acid and Vitamin E for Abnormal Uterine Bleeding Caused by Intrauterine Device(IUD)

目的:探讨氨甲苯酸联合维生素E治疗宫内节育器(IUD)致子宫异常出血的临床疗效。方法:将119例IUD致子宫异常出血患者随机分为观察组和对照组,观察组给予口服氨甲苯酸片联合维生素E胶囊,对照组给予口服宫血宁胶囊,观察用药后的治愈率。结果:观察组(n=61)治疗子宫异常出血总有效率100.00%,其中治愈50例(81.97%)、显效11例(18.03%)。对照组(n=58)总有效率为77.59%,其中治愈24例(41.38%)、显效21例(36.20%)、无效13例(22.41%)。组间总有效率差异有统计学意义(P<0.005)。对患者经量增多、经期延长、经间出血率的治疗效果,组间差异也有统计学意义(P<0.05)。结论:氨甲苯酸联合维生素E治疗IUD所致的子宫异常出血疗效确切,具有一定的临床推广价值。

Objective： To study the effects of aminomethylbenzoic acid combined with vitamin E on the treatment of abnormal uterine bleeding （AUB） caused by intrauterine device （IUD）. Methods： A total of 119 patients with abnormal uterine bleeding after IUD insertion were randomly divided into observation group （n=61） and control group （n=58）. Observation group were given aminomethylbenzoic acid combined with vitamin E and control group were only given Gongxuening capsule. The effective rates in the two groups were compared. Results： The total effective rate of abnormal uterine bleeding of observation group was 100.00%, 50 cases were cured （81.97%）, 11 cases were markedly improved （18.03%）. The total effective rate of abnormal uterine bleeding of control group was 77.59%, 24 cases were cured （41.38%）, 21 cases were markedly improved （36.20%）, and 13 cases were invalid （22.41%）. The effective rate of abnormal uterine bleeding of obserbation group was significantly higher than that of control group （P〈0.005）. Between the two groups, the therapeutic effects of heavy menstrual bleeding, menstrual prolongtation and the intermittent bleeding were statistically significant （P〈0.05）. Conclusion： The combined treatment with aminomethylbenzoic acid and vitamin E for IUD-caused AUB is effective. It could be necessary for the combined treatment to be further used and studied clinically.