P2X7受体在病理性疼痛中的研究进展

Progress of P2X7 Receptor Research in Chronic Pain

病理性疼痛主要包括组织损伤或炎症引起的炎症痛、神经系统损伤或疾病引起的神经病理性疼痛和恶性肿瘤及治疗引起的癌症痛三大类。病理性疼痛对常规的镇痛药物反应不理想,迫切需要寻找新的对病理性疼痛更有效和更特异的治疗手段。P2X7受体作为离子通道型嘌呤能受体,在炎症痛、神经病理性疼痛和癌症痛中都具有重要作用。靶向P2X7受体的新药物将为病理性疼痛的治疗带来新的希望。该文综述了P2X7受体在三类病理性疼痛中的研究进展。

Pathological pain can be usefully divided into three categories, inflammatory pain, a pain related to peripheral tissue damage/inflammation, neuropathic pain, pain mainly associated with peripheral nerve injury or illness, and cancer pain, pain induced by tumors infiltrating/metastasizing and resulting from treatment. Treatment of chronic pain is always accompanied by a poor response, thus, effective therapeutic strategy is imminently needed. P2X7 receptor is one of the purinergic receptors, and belongs to ligand gating non selective ion channel. Numerous studies imply a critical role of P2X7 receptor in chronic pain. Targeting to P2X7 receptor will be a new approach for treatment of pathological pain. In this paper, we reviewed the progress of P2X7 receptor in chronic pain.