当飞利肝宁片治疗抗精神病药物所致轻度肝功能损伤疗效观察

Treatment of Antipsychotics Induced Mild Hepatic Damage by Dangfei Liganning Tablet:an Efficacy Observation

目的观察当飞利肝宁片治疗精神病药物所致肝功能损伤的疗效。方法将服用抗精神病药物导致轻度肝功能损伤的80例住院精神病患者随机分为当飞利肝宁片治疗组(治疗组,40例)和护肝片治疗组(对照组,40例),治疗组口服当飞利肝宁片,每次2片,每天3次;对照组口服护肝片,每次4片,每天3次,两组均治疗4周。观察治疗前及治疗1、2、4周后ALT、AST变化情况,比较两组疗效。结果与本组前一时间点比较,两组治疗1、2、4周ALT、AST逐渐降低(P<0.05)。治疗组治愈率、总有效率分别为72.5%、97.5%,对照组治愈率、总有效率分别为62.5%、90.0%,两组治愈率及总有效率差异无统计学意义(P>0.05)。两组均未出现明显不良反应。结论当飞利肝宁片可以安全有效地治疗抗精神病药物所致肝功能损伤。

Objective To observe the therapeutic efficacy of Dangfei Liganning Tablet （DLT） in the treatment of antipsychotics induced mild hepatic damage. Methods Totally 80 mental inpatients with antipsychotics induced mild liver injury were randomly assigned to two groups, the treatment group （40 cases） and the control group （40 cases）. Patients in the treatment group took DLT, two tablets each time, three times per day, while those in the control group took Liver-protecting Tablet （LT）, four tablets each time, three times per day. The treatment course was 4 weeks for all. Changes of glutamic-pyruvic transaminase （ALT） and glutamic-oxalacetic transaminase （AST） were observed before treatment, week 1,2, and 4 after treatment. The therapeutic efficacy was compared between the two groups. Results Compared with the former time point, ALT and AST gradually decreased in the two groups at week 1, 2, and4 （P 〈0.05）. The cured rate was 72.5% and the total effective rate was 97.5% in the treatment group. They were 62.5% and 90.0% respectively in the control group. There was no statistical difference in the two indices between the two group （P 〉0.05）. No obvious adverse reaction occurred in the two groups. Conclusion DLT could treat antipsychotics induced mild hepatic damage in a safe and effective way.