美金刚联合语言训练治疗卒中后失语患者的临床研究

Effects of memantine and speech-language therapy on patients with poststroke aphasia

目的观察美金刚联合语言训练(SLT)治疗卒中后失语患者的临床疗效。方法 32例卒中后失语恢复期患者随机分为对照组(n=15)和试验组(n=17),采用汉语标准失语症检查对治疗前后语言功能进行评估。对照组采用SLT治疗,试验组采用美金刚(20 mg·d-1)联合SLT治疗,持续6周。结果比较治疗前后语言功能的各个项目总分,两组患者听理解、复述、说、出声读、阅读理解、抄写、描写、听写等项目均有显著差异,治疗后较治疗前有明显改善(P<0.05);试验组在听理解、说、阅读理解、抄写四方面语言功能较对照组改善更为显著(P<0.05)。结论美金刚联合SLT治疗比单纯SLT治疗能更明显改善卒中后恢复期失语患者的语言功能。

AIM To observe the efficacy of both memantine and speech- language therapy （SLT） on patients with poststroke aphasia. METHODS Thirty- two patients with aphasia during convalescence were randomized to control group （n = 15） and treatment group （n = 17）, which were treated with SLT alone or memantine （20 mg ·d^-1） combined with SLT. Outcome measures were administrated with Chinese standard aphasia examination. RESULTS Both two groups showed all kinds of language abilities improved obviously after the treatment （P 〈 0.05） . The treatment group showed significantly better improvement on the functions of listening, oral expression, reading comprehension and copying than the control group （P 〈 0.05） . CONCLUSION Combining memantine and SLT can improved language abilities more significantly than SLT alone on patients with aphasia during convalescence after stroke.