microRNA与乳腺癌浸润转移关系的研究进展

Advance in Study of MicroRNA in Invasion and Metastasis of Breast Cancer

目的总结microRNA(miRNA)与乳腺癌浸润、转移关系的研究进展。方法检索并筛选近年来国内外发表的有关miRNA与乳腺癌浸润、转移关系的文献并对其进行综述。结果许多miRNA在乳腺癌发生、发展与浸润、转移过程中都起着关键作用,按其作用可分为促癌miRNA(miR-21、miR-10b等)和抑癌miRNA(miR-31、let-7等)两类。结论 miRNA调控乳腺癌浸润及转移的具体过程还需要更多、更详细的实验研究。

Objective To summarize the relationship of microRNA （miRNA） to metastasis and invasion of breast cancer. Method Domestic and international publications involving the relationship of miRNA to breast cancer were screened and reviewed. Results miRNA played a key role in the process of breast cancer metastasis. According to its function, it could be distinguished from cancer-promoting gene （such as miR-21, miR-10b, etc. ） to suppressor gene （such as miR-31, let-7, etc. ）. Conclusion The more detailed experimental studies about the relationship of miRNA to metastasis and invasion of breast cancer need to be researched in order to provide a new method for the diagnosis and treatment of breast cancer metastasis and invasion.