宫颈癌淋巴结转移相关因素的分析

Analysis of the Relative Factors of Lymph-nodes Metastasis in Patients with Cervical Cancer

目的通过分析宫颈癌淋巴结转移与各临床病理因素的关系,探讨影响宫颈癌淋巴结转移的高危因素。方法收集2005年1月-2010年12月间行手术治疗的136例临床ⅠA-ⅡA期宫颈癌患者的临床病理资料,将淋巴结转移与各临床病理因素之间的关系进行单因素χ2检验及多因素logistic回归分析。结果总的淋巴结转移率为14.0%(19/136),其中以闭孔淋巴结转移为主(占63.2%),其次为髂内外淋巴结(占42.1%),而腹股沟深淋巴结、腹主动脉旁淋巴结均无转移。单因素分析显示临床分期、间质浸润深度、肿瘤病理类型、宫旁浸润、阴道浸润与淋巴结转移间具有相关性(P<0.05);而多因素分析显示仅临床分期、肿瘤病理类型、间质浸润深度与淋巴结转移相关。结论临床分期、肿瘤病理类型、间质浸润深度为淋巴结转移的高危因素。

Objective To analyze the relative factors of lymph-nodes metastasis （LM） in patients with cervical cancer. Methods The clinico-pathological data of 136 patients with stage I A- 1I A of cervical cancer who underwent surgical therapy from January 2005 to December 2010 were retrospectively analyzed. The correlation between clinico- pathological parameters and LM was analyzed by univariable Z2 analysis and multivariable logistic analysis. Results The total LM rate （LMR） was 14.0% （19/136）. The rate of LM in obturator was the highest （63.2%）, and then the rate between the external and internal iliac was 42.1%. The rate of deep inguinal lymph nodes and para-aortic lymph node was 0.0%. There was correlation between the clinic staging, depth of stromal invasion, histologic subtype, parametrial invasion, vaginal invasion and LM in univariable analysis （P 〈 0.05）. While in multivariable analysis, the correlation with LM was only existed between the clinic staging, histologic subtype, depth of stromal invasion and LM. Conclusion Clinic staging, histologic subtype, depth of stromal invasion are high risk factors of LM.