多药耐药相关蛋白1及其与肿瘤关系的研究进展

Adervances in the research of multidrug resistance-associated protein 1 and its relationship with tumor

多药耐药(MDR)是导致临床肿瘤化疗失败的重要原因。多药耐药相关蛋白1(MRP1/ABCC1)被认为是介导肿瘤多药耐药的主要跨膜转运蛋白之一。探究MRP1/ABCC1的结构、功能,以及与肿瘤的关系,有利于指导临床合理用药和肿瘤预后的评估。

Multidrug resistance（MDR）is a major impediment to the cancer chemotherapy.Multidrug resistance associated protein 1（MRP1/ABCC1）is thought to be one of the main transmembrane proteins that mediate tumor multidrug resistance.Exploring its structure and function,as well as the relationship between MRP1/ABCC1and tumor,will be beneficial to provide an optimal strategy and evaluate the prognosis of tumor.