口腔鳞癌患者Ki-67、VEGF和P16表达与平阳霉素诱导化疗疗效间关系的研究

Association between expression of Ki-67,EGF and P16 and the effect of induction chemotherapy by Pingyangmycin in oral cancer patients

目的探讨口腔鳞癌(OSCC)患者Ki-67、VEGF和P16表达强度与诱导化疗敏感性间的关系。方法采用免疫组化法,检测103例口腔鳞癌患者活检标本及手术切除原发灶标本中Ki-67、VEGF和P16的表达,同时观察该组患者平阳霉素诱导化疗疗效。分析两者间关系。结果 OSCC患者平阳霉素诱导化疗前Ki-67和VEGF的表达强度和化疗效果有关。随着Ki-67和VEGF表达的增强,化疗有效率也提高(P<0.05)。平阳霉素诱导化疗后Ki-67、VEGF表达强度减弱。化疗前P16表达强度与疗效无显著相关性(P>0.05)。结论 Ki-67和VEGF表达强度与OSCC患者平阳霉素诱导化疗疗效有相关性,可作为预测平阳霉素诱导化疗疗效的参考。

Objective To investigate the association between the expression of Ki-67, VEGF and P16 and the effect of induction chemotherapy by Pingyangmycin in OSCC patients. Methods The expression of Ki-67 ,VEGF and P16 was examined and the effect of induction chemotherapy by Pingyangmycin evaluated in 103 OSCC patients. The association between the expression and the clinical results of chemotherapy was analyzed. Results The expression intensity of Ki-67 and VEGF and the effects of induction chemotherapy were related, the more intense of the expression, the higher effectiveness of the chemotherapy（ P 〈 0.05 ）. The expression intensity of P16 was not related to the induction chemotherapy （P 〉 0. 05）. Conclusion There was a correlation between the expression of Ki-67 and VEGF and the effect of induction chemotherapy by Pingyangmycin in OSCC patients. Ki-67 and VEGF may serve as a reference for predicting the outcomes of induction chemotherapy by Pingyangmycin.