β-tubulin Ⅲ的表达在局部晚期宫颈癌新辅助化疗中的意义

Significance ofβ-tubulin Ⅲexpression in the neoadjuvant chemotherapy of locally advanced cervical carcinoma

目的：探讨局部晚期宫颈癌组织中β-tubulin Ⅲ的表达及其在宫颈癌新辅助化疗中的意义。方法收集62例局部晚期宫颈癌患者肿瘤标本，采用免疫组化方法检测患者组织标本中β-tubulin Ⅲ的表达，并分析检测结果与宫颈癌临床病理特征的关系；按化疗方案分为两组，TP化疗组34例给予紫杉醇/顺铂（卡铂）方案化疗，PF化疗组28例给予5-氟尿嘧啶/顺铂方案化疗，2个疗程后评价疗效，分析TP方案和PF方案新辅助化疗后局部晚期宫颈癌的有效率及手术率，评估β-tubulinⅢ的表达在宫颈癌新辅助化疗中的意义。结果局部晚期宫颈癌组织中β-tubulinⅢ阳性表达率为62.90％；β-tubulinⅢ的表达与患者病理类型、分级及分期无关；β-tubulin Ⅲ的表达与TP方案化疗的有效率及手术率有关，β-tubulin Ⅲ阴性者化疗有效率和手术率分别为83.33％和83.33％，高于β-tubulinⅢ表达阳性者（59.09％，50.00％）（ P ＜0.05）；β-tubulinⅢ的表达与PF方案化疗的有效率和手术率无关（ P ＞0.05）；TP方案化疗的有效率及手术率高于PF方案化疗，但差异无统计学意义（ P ＞0.05）。结论在宫颈癌局部晚期新辅助化疗中，β-tubulin Ⅲ的表达情况可作为预测含紫杉醇联合化疗有效率和指导患者个体化化疗的重要指标。

Objective To investigate the β-tubulin Ⅲexpression in locally advanced cervical cancers and its significance in the neoadjuvant chemotherapy of cervical cancer .Methods Immunohistochemistry was used to detect the expression of β-tubulin Ⅲin tissue samples from 62 cases of locally advanced cervical cancer patients .Groups paclitaxel ＋cisplatin/carboplatin （TP） （34 pa-tients） underwent two cycles of TP chemotherapy ,while group 5-fluorouracil＋cisplatin（PF） （28 patients） underwent two cycles of PF chemotherapy .Comprehensive analysis of β-tubulinⅢexpressions of TP and PF neoadjuvant chemotherapies revealed the efficien -cy and operation rate .Results The positive rate ofβ-tubulin Ⅲ was 62.90% in locally advanced cervical cancer .β-tubulin Ⅲ ex-pression was not correlated with clinicopathological features in locally advanced cervical cancer （ P ＆gt;0.05 ） .β-tubulinⅢexpression was correlated with efficiency and operation rate with TP chemotherapy but not with PF chemotherapy .Conclusions In the neoadju-vant chemotherapy of locally advanced cervical cancers ,β-tubulinⅢexpression can be used as an important index to predict the effec-tive rate of combined chemotherapy containing paclitaxel and guide the patients to individual chemotherapy .