摘要
目的:探讨免疫组化在肺小细胞癌(SCLC)和肺非小细胞癌(NSCLC)鉴别诊断中的作用。方法应用免疫组化SP法,选择肺穿刺及支气管镜活检标本,病理形态疑似SCLC 共72例,检测CD56、Syn、TTF1、CK5/6、CK14、P63、CK7及NapsinA的蛋白表达,分析SCLC的病理形态特征和免疫表型特点及其与NSCLC的鉴别。结果72例肺癌患者中,SCLC共27例,低分化鳞状细胞癌(SCC)共17例,低分化腺癌(ADC)共28例。结论 SCLC和NSCLC在临床治疗上方法不同,充分应用免疫组化可以进行诊断和鉴别诊断,从而可以减少误诊,同时给临床治疗方案的选择提供重要依据。
Objective To investigate the role of immunohistochemistry in the differential diagnosis between small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC).Methods The protein expressions of CD56, Syn, TTF1, CK5/6, CK14, P63, CK7, and NapsinA in percutaneous lung biopsy and bronchoscopic biopsy specimens which were suspected as SCLC were examined by immunohistological streptavidin-peroxidase ( SP) method to analyze the pathological characteristics , immunological pheno-typical features , and differential diagnosis between SCLC and NSCLC .Results Among 72 cases of lung cancer patients ,there were 27 cases of SCLC,17 cases of low differentiated squamous cell carcinoma ( SCC) and 28 cases of low differentiated adenocarcinoma ( ADC) .Conclusions It is the different therapy between SCLC and NSCLC , immunohistochemistry analysis of biopsy can provide ac-curate diagnosis of SCLC and NSCLC , which will result in less misdiagnosis and provide an important valuable in the selection of clini -cal treatment protocols for lung cancer patients .
出处
《中国医师杂志》
CAS
2014年第4期488-490,共3页
Journal of Chinese Physician
关键词
癌
非小细胞肺
诊断
癌
小细胞
诊断
肺肿瘤
诊断
活组织检查
诊断
鉴别
免疫组织化学
Carcinoma,non-small-cell lung/diagnosis
Carcinoma,small cell/diagnosis
Lung neoplasms/diagnosis
Biopsy
Diagnosis,differential
Immunohistochemistry