再论甲状腺功能与女性生殖

Thyroid function and female reproduction

甲状腺功能异常在育龄妇女中较常见,包括甲状腺功能亢进、甲状腺功能减退及自身免疫性甲状腺炎,由此增加了孕期流产、早产及降低妊娠的几率,并对妊娠结局及辅助生殖技术(ART)的结局产生不良影响,引起这种情况的原因可能是甲状腺疾病直接干扰了正常的卵巢功能,间接影响了性激素结合球蛋白的分泌。鉴于甲状腺功能异常的妇女有明显增加不孕不育和流产的风险,因此建议在高危人群中进行甲状腺功能的筛查,妊娠早期阶段给予适当处理以有效降低妊娠不良结局的发生。

Thyroid dysfunction is common in women during the reprodiactive yearg of their lives, including hyperthyroidism, hypothyrodism and autoimmune thyroiditis （AIT）. Th＇yroid dysfunction ＇is known to increase the incidence of abortion and premature birth, reduce the likelihood of pregnancy, and adversely affect pregnant outcomes of assisted reproductive technology（ART）. Thyroid disorders can directly interfere with normal ovarian ＇function and indirectly affect on sex hormone binding g＇lobulin （SHBG）secretion. As the women with thyroid dysfunction have a significantly increased risk of infertility and clinical miscarriage,it is advisable to screen the thyroid function in high risk women to determine the presence of women with thyroid diseases. Furthermore,these patients should be treated properly at early gestational stages to reduce effectively the occurrence of adverse pregnant outcomes.