色谱-质谱联用技术测定人体内类固醇激素的研究进展

Research progress in steroid hormone analysis in vivo by chromatography-mass spectrometry

类固醇激素是高效能的生物化学物质,在多种生理活动中发挥显著的调节作用,但在体内的含量极低,因此对其进行准确定量具有重要意义。在各种检测方法中,色谱-质谱联用技术因具有高效、快速、灵敏的优点而得以广泛应用。笔者综述近年来色谱-质谱联用技术在内源性类固醇激素测定中的应用,为进一步的临床研究提供参考依据。

Steroid hormones were chemical compounds of high efficiency , which played a significant role in various physiological activities.However, the concentrations of hormones in vivo were extremely low, so it was very important for their accurate quantification.Chromatography-mass spectrometry technology was widely employed because of advances in high efficient , rapid and sensitive. The application of steroid hormone analysis by chromatography-mass spectrometry was reviewed in this paper , which could provide reference for furthuer clinical research .