抗菌药物应用专项整治前后鲍曼不动杆菌耐药情况研究

Study on drug resistance of Acinetobacter baumannii before and after special antibacterial drugs remediation

目的：调查抗菌药物应用专项整治前后鲍曼不动杆菌的耐药情况和各类抗菌药物的使用强度，为后续干预策略提供证据。方法分析2011、2012年检出的562例鲍曼不动杆菌及药敏实验结果，结合各时间段每类抗菌药物使用情况进行分析。结果2011-2012年鲍曼不动杆菌半年检出菌数无明显差异；通过抗菌药物应用专项整治，β-内酰胺的使用强度（antibiotics use density，AUD）、氟喹诺酮和氨基糖苷类的AUD分别下降22．22（31．92％）、4．19（46．29％）、5．24（68．83％）；β-内酰胺类耐药率降幅明显，下降25％～30％；氟喹诺酮类和氨基糖苷类的耐药率也有所下降，从50％临界点下降至2012年下半年的20％～30％。结论规范各类抗菌药物的使用强度有助于降低细菌耐药性。

Objective To investigate the drug resistance of Acinetobacter baumannii and antibiotics use density of all kinds of antibacterial drugs before and after special antibacterial drugs remediation , provide evidence for the follow-up intervention strategies . Methods The experimental results of detected 562 cases Acinetobacter baumannii and sensitivity test were analyzed in our hospital in 2011-2012 , combined with using of every type of antibacterial drugs on different time period .Results The number of bacteria detec-ted half year had no significant difference during 2011-2012 .The antibiotics use density of beta-lactam、fluroquinoloncs and aminogly-cosides declined 22.22（31.92%）、4.19（46.29%）、5.24（68.83%） respectively by special antibacterial drugs remediation .Beta-lactam resistance rates declined significantly to 25%~30%, fluroquinoloncs and aminoglycosides resistance rates also declined , from 50%of the critical point to 20%~30%in the second half of 2012 .Conclusion Standardization of antibiotics use density of various antibacterial drugs could help reduce bacterial resistance .