浸润性乳腺癌中CRABPⅡ和E-FABP的差异表达及与临床病理的关系

The relationship of different expressions of cellular retinoic acid-binding protein Ⅱ and epidermal fatty acid-binding protein with the clinical pathology in the invasive breast cancer

目的 :探讨细胞视黄酸结合蛋白(cellular retinoic acid-binding proteinⅡ,CRABPⅡ)和表皮脂肪酸结合蛋白(epidermal fatty acid-binding protein,E-FABP)的差异表达在乳腺癌中的意义,以及与临床病理特征和分型的关系。方法:分析123例浸润性乳腺癌患者的临床资料,采用免疫组化法检测乳腺癌组织中CRABPⅡ和E-FABP的表达。结果:CRABPⅡ和E-FABP在浸润性乳腺癌的表达存在显著差异(P<0.01)。此差异表达分为E-FABP≥CRABPⅡ与E-FABP﹤CRABPⅡ两种。在浸润性乳腺癌中,E-FABP≥CRABPⅡ的表达较多见。CRABPⅡ和E-FABP的差异表达与腋窝淋巴结转移和TNM分期有关(P<0.05)。差异表达与病理分型相关,Luminal A型中E-FABP≥CRABPⅡ的百分率最低(61.6%),Basal-like型中的百分率最高(95.2%)。结论 :在浸润性乳腺癌中,CRABPⅡ和E-FABP的差异表达可能与乳腺癌的侵袭性及预后相关,E-FABP≥CRABPⅡ时的乳腺癌侵袭性高、预后差。

Objective：To explore the signiifcance of the different expressions of cellular retinoic acid-binding proteinⅡ（CRABP Ⅱ ） and epidermal fatty acid-binding protein （E-FABP） in the breast cancer and the relationship of their clinical pathological features and types. Methods： The clinical data on 123 cases with invasive breast cancer were analyzed and the expressions of CRABP Ⅱand E-FABP were detected by immunohistochemistry in the breast cancer tissues. Results：There existed different expressions between CRAB Ⅱand E-FABP in the invasive breast cancer （P〈0.01）, which could be classiifed into two types of E-FABP≥CRABP Ⅱand E-FABP〈CRABPⅡ. The expression of E-FABP≥CRABP II was seen more in the invasive breast cancer. The different expressions of CRABP II and E-FABP were related to axillary lymph node metastasis and TNM staging. Different expression was related to pathological types. The percentage rate of E-FABP≥CRABPⅡwas the lowest in Luminal A subtype （61.1%） and the highest （95.2%） in Basal-like type. Conclusions：In the invasive breast cancer the different expressions of CRABP Ⅱand E-FABP may have the relationship with the invasion and prognosis of the breast cancer. When E-FABP is ≥CRABPⅡ, the breast cancer has higher invasion and its prognosis is poor.