带式真空干燥技术在参松养心胶囊中试生产中的应用分析

Application Research of Vacuum Belt Drying Technology on Pilot-scale Production of Shensong Yangxin Capsules

目的:探讨带式真空干燥技术在参松养心胶囊生产中应用的可行性。方法:在相同提取、浓缩工艺条件下,以收粉率、休止角、吸湿率、堆密度及有效成分含量为指标,考察带式真空干燥和喷雾干燥工艺制备的参松养心胶囊差异性。结果:带式真空干燥和喷雾干燥样品的休止角分别为30.3,32.3°,堆密度0.65,0.55 g·cm-3,收粉率23.51%,22.35%,总干燥时间4.47,7.20 h,72 h吸湿率20.7%,28.6%,芍药苷、盐酸小檗碱质量分数均依次为0.36%,0.75%。结论:带式真空干燥技术在参松养心胶囊中试生产中可行性强,制备的样品质量较好,且能提高生产效率。

Objective： To investigate feasibility of vacuum belt drying technology on pilot-scale production of Shensong Yangxin capsules. Method： Under the same conditions of extraction and concentration, regarding yielf of powder, angle of repose, bulk density, percentage of moisture and contents of effective ingredients as indicators to investigate difference of vacuum belt drying process and spray drying technology for preparing Shensong Yangxin capsules. Result： In samples of vacuum belt drying and spray drying, yield of powder were 23.51% , 22. 35% , angle of repose were 30. 3, 32. 3°, bulk density were 0. 65, 0. 55 g·cm^-3, total drying time were 4.47, 7.20 h, percentage of moisture in 72 h were 20.7% and 28.6% , concentrations of paeoniflorin and berberine hydrochloride were 0.36% and 0.75% , respectively. Conclusion： Vacuum belt drying technology was highly feasible on pilot-scale production of Shensong Yangxin capsules with good quality products and high production efficiency.