葛根素注射液辅助治疗急性前壁心肌梗死的系统评价

Systemic Review of Puerarin Injection of Adjuvant Therapy for Acute Anterior Wall Myocardial Infarction

目的:系统评价葛根素注射液辅助治疗急性前壁心肌梗死的疗效及安全性。方法:全面收集葛根素注射液用于辅助治疗急性前壁心肌梗死的随机对照试验,采用Cochrane风险评价表评价其研究质量,提取资料并通过RevMan 5.2进行Meta分析。结果:共纳入6篇文献,共计受试者354例,1篇文献采用抽签确定随机序列,其他均未提及随机分组方法及盲法。Meta分析显示,葛根素注射液辅助西医常规疗法治疗急性前壁心肌梗死具有较好的疗效,可以有效降低QRS记分[MD=-1.69,95%CI(-2.07,-1.32),P<0.000 01],提高左心室射血分数[MD=12.18,95%CI(2.97,21.39),P=0.010],减少梗死面积[MD=-9.46,95%CI(-11.37,-7.55),P<0.000 01],提高红细胞超氧化物歧化酶(SOD)值[MD=611.47,95%CI(464.80,758.14),P<0.000 01],降低死亡率,仅报道1例不良事件。结论:葛根素注射液辅助治疗前壁心肌梗死具有较好的疗效和安全性。

Objective： To evaluate systematically the clinical efficacy and safety of puerarin injection for the adjuvant therapy of acute anterior wall myocardial infarction. Method ： Randomized controlled trials （RCTs） about puerarin injection for acute anterior wall myocardial infarction were searched systemically and comprehensively. Two reviewers assessed the quality of the included studies by the Cochrane risk of bias, and extracted the information from them. Meta-analysis was conducted with the software Review Manager 5.2. Result： A total of 6 studies with 354 participants were included, and the quality of the studies was relatively low. There was only one study to generate random sequence by drawing lots. In the meta-analysis, the results of puerarin group were significantly superior to the west conventional therapy group in decreasing the score of QRS [ MD = - 1.69, 95%CI （ -2.07, - 1.32）, P 〈0.000 01], reducing the infarct size [MD = -9.46, 95%CI （ - 11.37, - 7.55） ,P 〈 0. 000 01 ], increasing the ejection fraction left ventricular ejection fraction （LVEF） [ MD = 12.18, 95% CI （2.97, 21.39） , P = 0. 010 ] and erythrocyte superoxide dismutase （SOD） values [ MD = 611.47, 95% CI （464.80, 758. 14）, P 〈0. 000 01 ] , and reducing mortality rate, and so on. And there was only 1 adverse drug reaction （ADR） reported, more quality studies should be included. Conclusion： Comparing with the conventional therapy of the control group used for treating acute anterior wall myocardial infarction, puerarin injection combined with the conventional therapy was relatively effective and safety, which was based on the systematic review.