市售止泻药品监测销量与腹泻发病的相关性研究

A Study on Relationship between Anti-diarrhea Medicine Sales Volume and the Incidence of Diarrhea in Hangzhou

目的了解杭州市止泻药品销量监测结果与全市腹泻症状发病数的相关性,探讨药品销量监测与传染病发病的关系及其应用。方法搜集杭州市华东武林大药房2006—2012年克痢莎、黄连素及思密达3种非处方止泻药品的销售数据并标化。统计杭州市9家医院的感染性腹泻及非感染性腹泻发病数,分别与药品销量作相关性分析。结果 2006—2012年监测期间,黄连素日销量标化的用药天数(DDD)最大,DDD中位数为1 600.32。2007、2008及2012年止泻药销量DDD高峰出现在7月,2006、2009及2010年高峰出现在8月。相关性分析结果显示:2006、2007、2008及2010年的药品销量与感染性腹泻呈正相关,相关系数分别为0.635、0.448、0.298及0.217(P均<0.01)。7年总的相关系数为-0.555(P<0.01)。2006—2008年的非感染性腹泻发病数与药品销量也呈正相关,3年总的相关系数为0.419(P<0.01)。结论杭州市药品销量监测系统中止泻药销量与感染性及非感染性腹泻均呈正相关,表明药品销量监测对于早期发现肠道病暴发流行有积极作用。

Objective To examine the association between anti- diarrhea medicine sales volume and the reported cases of intestinal infectious diseases in Hangzhou. Methods Sales data of three over- the- counter drugs including G dysentery Sha,berberine and Smecta from 2006 to 2010 were collected and standardize. Correlations between out- patient cases of infectious and non- infectious diarrheal from 9 hospitals and medicine sales volume were analyzed respectively. Results From 2006 to 2010,berberine had the highest standardized daily drug dose（ DDD） with median 1 600. 32. The peak of DDD occurred on July in year 2007,2008 and 2012; while on August in year 2006,2009 and 2010. There was positive correlation between medicine sales volume and infectious diarrhea in year 2006,2007,2008 and 2010,the correlation coefficients were 0. 635,0. 448,0. 298 and 0. 217 respectively（ P〈0. 01）. The same correlation was occurred in non-infectious diarrhea in year 2006 to 2008 as well and the total correlation coefficient of the three years was 0. 419（ P〈0. 01）. Conclusion A positive correlation has been found between the anti- diarrheal medicine sales volume and incidence of infectious and non- infectious intestinal diseases,demonstrating that pharmacy monitoring could have a positive effect on early detection of outbreaks of intestinal diseases.