体检人群血浆致动脉硬化指数及超敏C反应蛋白与血糖水平的关系研究

A Study on Correlations between Atherogenic Index of Plasma,High Sensitive C Reactive Protein and Blood Glucose among Physical Examination Population

目的研究体检人群血糖(GLU)与血浆致动脉硬化指数(AIP)、超敏C反应蛋白(HCRP)、血脂系列等指标的相关性,为临床评估高血糖及并发心脑血管疾病风险提供实验检测依据。方法使用奥林巴斯AU5400全自动生化分析仪测定9 057名体检人员GLU、HCRP及血脂系列等指标,计算AIP值,用t检验或方差分析不同性别、年龄、血糖组间这些测定指标的差异;采用Pearson相关分析各指标之间的相关性,再用多因素Logistic回归分析高血糖的相关危险因素。结果男女高血糖组AIP、HCRP水平均高于非高血糖组人群(P<0.01)。GLU与AIP、载脂蛋白B(apoB)、HCRP、低密度脂蛋白-胆固醇(LDL-C)、总胆固醇(TC)、甘油三酯(TG)、尿酸(URIC)、apoB/apoA1呈较低程度的正相关,其中与AIP相关性最高(r=0.163,P<0.01);GLU与载脂蛋白A1(apoA1)、高密度脂蛋白胆固醇(HDL-C)呈负相关。多因素Logistic回归分析显示:男性、年龄、HCRP、AIP和高血糖存在关联。结论高血糖人群的AIP、HCRP平均水平高于非高血糖人群。建议2型糖尿病患者应重视血糖、AIP和HCRP等指标的监控,以为防止并发心脑血管疾病。

Objective The aim was to find the correlations between blood glucose（ GLU） and atherogenic index of plasma（ AIP）,high sensitive C reactive protein（ HCRP）,plasma lipid profiles among physical examination population. Methods The parameters including GLU,HCRP,and plasma lipid profiles were examined by using Olympus AU5400 automatic biochemical analyzer from 9 057 blood samples,and then AIP value was calculated. The t test,Pearson correlation and multivariate logistic regression were used. Results The levels of AIP and HCRP were significantly higher in high glucose group both in males and females（ P 0. 01）. Positive lower correlations were found between GLU and AIP,apolipoprotein B（ apoB）,HCRP,low density lipoprotein cholesterol（ LDL- C）,total cholesterol（ TC）,triglyceride（ TG）,uric acid（ URIC） and apoB/aopA1,while the correlation with AIP was highest（ r = 0. 163,P 0. 01）. There were negative correlations between GLU and apoA1,high density lipoprotein cholesterol（ HDL- C）. Results of multivariate logistic regression analysis showed that male gender,age,HCRP and AIP were relative factors associated with hyperglycemia. Conclusion There are some differences in the levels of AIP and HCRP between the high glucose people and general people.