摘要
目的探讨卒中相关性肺炎患者血清Th1/Th2细胞因子[干扰素-γ(IFN-γ),白细胞介素-4(IL-4)]水平的变化及意义。方法采用酶联免疫吸附试验法(ELISA法)检测34例卒中相关性肺炎(卒中相关性肺炎组)、36例卒中(卒中组)和30例健康体检者(健康对照组)血清IFN-γ、IL-4水平。结果与健康对照组、卒中组比较,卒中相关性肺炎组血清IFN-γ、IFN-γ/IL-4比值均明显降低(均P<0.05),血清IL-4水平明显升高(P<0.05)。结论卒中相关性肺炎患者的IFN-γ减少,lL-4增多,Th1/Th2细胞介导的细胞免疫可能与卒中相关性肺炎的免疫功能失衡有关。
Objective To investigate the changes in serum Th1/Th2 cytokines,interferon-γ（IFN-γ） and interleukin-4 （IL-4）,in patients with stroke-associated pneumonia （SAP）and their significance. Methods Serum levels of IFN-γ and IL-4 were measured by ELISA in 34 patients with SAP （SAP group）,36 patients with stroke（stroke group）and 30 healthy subjects（control group）.Results Compared with control group or stroke group,IFN-γlevels and IFN-γ/IL-4 ratios significantly decreased but IL-4 levels significantly increased in SAP group（P＆lt;0.05）.Conclusion IFN-γ production decreases but IL-4 production increases in patients with SAP. Th1/Th2 cell-mediated immunity may be correlated with immune imbalance in SAP.
出处
《实用临床医学（江西）》
CAS
2014年第2期1-2,6,共3页
Practical Clinical Medicine
基金
江西省卫生厅科技计划(20131096)
