降低血尿酸水平延缓血液透析患者血管硬化临床观察

Effects of Lowering Serum Uric Acid Levels on Vascular Sclerosis in Hemodialysis Patients

目的：观察降低血尿酸水平对尿毒症血液透析患者血管硬化的保护作用。方法选择血透室行规律透析的60例患者为观察对象按随机数字表法分为治疗组和对照组，每组30例。治疗组在对照组维持性透析及综合药物治疗的基础上，给予别嘌醇片200～300 mg·d-1，治疗9个月。结果治疗组患者血尿酸水平、脉压、脉压指数均有明显降低，C-反应蛋白下降，与对照组比较差异有统计学意义（P〈0.05）。结论降低血尿酸水平能有效延缓血液透析患者血管硬化的进程。

Objective To investigate the protective effects of lowering serum uric acid levels on vascular sclerosis in uremic dialysis patients. Methods Sixty maintenance dialysis patients were randomly given comprehensive drug treatment （control group, n=30） or in combination with allopurinol tablets 200-300 mg·d-1 （treatment group, n=30）.tratment for 9 months.Results Compared with control group, serum uric acid levels, pulse pressure, pulse pressure index and C-reactive protein levels significantly decreased in treatment group（P〈0.05）.Conclusion The reduction of serum uric acid levels can significantly delay the process of vascular sclerosis in dialysis patients.