摘要
目的探讨EB病毒感染状况检测与甲状腺肿瘤良恶性的关系。方法分析2011年1月—2013年1月在医院接受住院手术治疗的甲状腺肿瘤患者的临床资料及手术标本,根据术后病理结果分为甲状腺癌组(观察组)和甲状腺腺瘤组(对照组)2组,检测比较2组患者的一般资料、炎性指标(包括C-反应蛋白CRP、血沉ESR和白介素6 IL-6)、降钙素原PCT、EBV评分及EBV评分对甲状腺肿瘤良恶性的预测价值。结果本研究共纳入研究对象80例,其中观察组44例,对照组36例。2组患者的术前炎性指标(包括CRP、ESR和IL-6)、PCT水平差异均无统计学意义(P均>0.05),而观察组的EBV评分显著高于对照组(t=4.756,P<0.01);观察组中不同病理类型的甲状腺癌患者之间EBV评分差异并无统计学意义(χ2=0.321,P=0.95);EBV评分对甲状腺肿瘤良恶性的预测价值的ROC曲线分析显示曲线下面积为0.900,敏感性为78.33%,特异性为88.32%。结论 EBV评分在甲状腺癌中的表达显著高于甲状腺腺瘤,其在甲状腺肿瘤良恶性预测和鉴别方面有着一定的价值。
Objective Our retrospective study was aimed to analyze the relationship between EB virus and thyroid neoplasm. Methods Clinical data of patients with thyroid neoplasm received treatment at our hospital from January,2011 to January,2013 was retrospectively analyzed. They were divided into two groups according to the pathological results. The general information,inflammatory markers including CRP,ESR,IL-6,PCT,the EBV score and the predictive value of EBV score of thyroid neoplasm were recorded. Results A total of 80 patients were retrospective analyzed,including 44 in observe group and 36 in control group. The score of EBV in observe group was significant higher than in control group. The inflammatory markers and PCT before the surgery in two groups were with no statistical meaning. The ROC curve of EBV score in the predictive value of thyroid neoplasm showed that AUC was 0. 900,the sensitivity was 78. 33% and specificity was 88. 32%. Conclusion The score of EBV in observe group was significant higher than in control group. The score of EBV had a certain value in the prediction of benign and malignant thyroid tumors.
出处
《中华全科医学》
2014年第7期1063-1065,共3页
Chinese Journal of General Practice
