凝血酶联合奥美拉唑治疗胃出血的疗效及安全性观察

Observation on Clinical Effect and Safety of Thrombin Combined with Omeprazole in the Treatment of Gastrorrhagia

目的观察凝血酶联合奥美拉唑治疗胃出血的疗效及安全性。方法选择70例胃出血患者,根据治疗方案不同分为两组各35例,观察组治疗上给予凝血酶联合奥美拉唑,对照组治疗上单用凝血酶。观察两组患者治疗总有效率、大便隐血转阴时间、平均住院时间等。此外,对两组患者治疗期间各类不良反应进行记录。结果观察组治疗总有效率为97.14%,高于对照组的77.14%,差异有显著性(P<0.05);观察组大便隐血转阴时间、平均住院时间与对照组比较,有明显缩短,差异均有显著性(P<0.05);治疗期间观察组不良反应发生率为2.86%,低于对照组的22.86%,差异有显著性(P<0.05)。结论凝血酶联合奥美拉唑治疗胃出血,疗效可靠,能够较短时间内止血,缩短住院时间,减轻患者经济压力。此外,不良反应较少,值得临床推广。

Objective To observe the clinical effect and safety of thrombin combined with omeprazole in the treatment of gastrorrhagia. Methods 70 patients with gastrorrhagia were randomly divided into two groups, with 35 cases in each group. The observation group was treated with thrombin combined with omeprazole, while the control group was treated with thrombin alone. The total effective rate, FOBT negative time, average hospital stays and adverse reactions during therapy were observed. Results The total effective rate of observation group was 97.14%, significantly higher than 77.14% of control group（P 0.05）; The FOBT negative time and average hospital stays of observation group were significantly shorter than those of control group（both P 0.05）; During treatment, the incidence of adverse reactions of observation group was 2.86%, significantly lower than 22.86% of control group（P 0.05）. Conclusions Thrombin combined with omeprazole has an accurate clinical effect for the treatment of gastrorrhagia. It can stop bleeding in a short time, shorten hospital stays,and relieve economic burdens of patients. Besides, it has few adverse reactions, so it is worthy of clinical application.