氟甲砜霉素(Florfenicol)在猪体内的药物动力学

Pharmacokinetics of Florfenicol in Pigs

健康猪 6头 ,体重 ( 2 4 .7± 1 .0 ) kg,单剂量静注、肌注、内服氟甲砜霉素 ( Florfenicol) 2 0 mg/ kg,用高效液相色谱法测定其血药浓度 ,实验所得的血药浓度 -时间数据采用非房室模型统计矩原理分析处理。静注给药的主要药物动力学参数为 :AUC 90 .1 3mg/ ( L· h) ,MRT 6.84 h,Cl B0 .2 3L/ ( kg· h) ,Vd(SS) 1 .53L/ kg,t1 / 2β 6.72 h。肌注给药的主要药物动力学参数为 :AUC 84 .31 mg/ ( L· h) ,MRT 2 6.88h,t1 / 2β 1 7.1 8h,F96.86% ,校正 F* 4 2 .50 %。内服给药的主要药物动力学参数为 :AUC1 32 .0 8mg/ ( L· h) ,MRT1 4 .2 3h,t1 / 2β 9.98h,F 1 4 8.53% ,校正 F* 1 0 8.51 %。试验结果表明 ,氟甲砜霉素在猪体内的主要药动学特征为 :静注给药表观分布容积大 ,消除半衰期长 ,血药浓度高 ;肌注给药吸收不规则 ,吸收和消除缓慢 ;内服给药吸收迅速完全 。

The pharmacokinetics of florfenicol was investigated in 6 healthy pigs.The plasma concentrations of florfenicol were determined by HPLC with UV detection at 223 nm.The plasma concentration time data derived from experiments were analyzed by non compartmental method based on statistical moment theory.The main pharmacokinetic parameters after intravenous administration were as follows:AUC 90.13 mg/(L·h),MRT 6.84 h,Cl B 0.23 L/(kg·h),Vd (SS) 1.53 L/kg,t 1/2β 6.72 h.The main pharmacokinetic parameters after intramuscular administration were:AUC 84.13 mg/(L·h),MRT 26.88 h,t 1/2β 17.18 h,F 96.86%,F * 42.50%.The main pharmacokinetic parameters following oral administration were:AUC 132.08 mg/(L·h),MRT 14.23 h,t 1/2β 9.98 h,F 148.53%,F * 108 51%.The pharmacokinetic characteristics of florfenicol after intravenous administration were large apparent distribution volume,wide distribution in the body,and high plasma level.After intramuscular administration of florfenicol in pigs,the absorption was irregular and retarded,and the elimination from the body was slow.The absorption of drug was complete and bioavailability value was high after oral administration.