加味四妙勇安汤联合前列腺素E1治疗下肢动脉硬化闭塞症的临床疗效

Clinical Effects of Jia Wei Si Miao Yong An Decoction Combined with Prostaglandin E1 in Treating Lower Limb Atherosclerosis Obliterans

目的:观察加味四妙勇安汤联合前列腺素E1治疗下肢动脉硬化闭塞症(ASO)的临床疗效。方法:120例双侧下肢ASO患者,以分层随机法分为两组,每组各60例。对照组用前列腺素E1 20μg静脉滴注,1次/天;治疗组在对照组治疗基础上,另口服加味四妙勇安汤,1剂/天,早晚各1次。30天为1个疗程,共4个疗程。观察两组的临床疗效,并测定治疗前后白介素-17A(IL-17A)、全血表观黏度、血浆黏度、血浆纤维蛋白原(FIB)水平变化。结果:治疗组治疗后总有效率优于对照组(96.67%vs 68.33%,P<0.05)。两组治疗后IL-17A、全血表观黏度、血浆黏度和FIB水平(除对照组外)与治疗前比较,均有显著下降(P<0.05),治疗组较对照组更低(P<0.05)。结论:加味四妙勇安汤联合前列腺素E1治疗下肢ASO疗效明显,能有效降低炎性反应,改善患者血液流变性。

Objective：To observe the clinical effects of Jia wei si miao yong an decoction combined with prostaglandin E1in treating lower limb arteriosclerosis obliterans.Method：120cases of bilateral lower limb arteriosclerosis obliterans were divided into two groups（60cases each）by stratified random method.Patients in both groups were given 20g prostaglandin E1to intravenous drip,once a day.In addition,Patients in treatment group were given Jia wei si miao yong an decoction,which was one agent a day and be taken twice in the morning and evening.The treatment was 30days a course,and 4courses in total.Then we observed the clinical effects and measured interleukin 17A（IL-17A）,apparent viscosity of whole blood,plasma viscosity,fibrinogen（FIB）level changes before and after treatment.Results：The total effective rate of the treatment group was 96.67%compared with 68.33%of the control group（P〈0.05）;the levels of IL-17A,apparent viscosity of whole blood,plasma viscosity and FIB（except the control group）after treatment in the two groups were significantly lower than before the treatment（P〈0.05）;and the level of treatment group were lower than that of the control group（P〈0.05）.Conclusion：The clinical effects of Jia wei si miao yong an decoction combined with prostaglandin E1in the treatment of lower limb arteriosclerosis obliterans was sure,it could obviously reduce the inflammatory reaction and effectively improve the index of blood rheology.