无症状炎症性前列腺炎与血清PSA水平的关系——防城港地区男性健康大型横断面调查

The relationship between asymptomatic inflammatory prostatitis and serum PSA level-A large prevalence survey of Fangchenggang area male health

目的探讨无症状炎症性前列腺炎与血清前列腺特异抗原(PSA)水平的关系。方法采用标准设计生活方式的调查问卷并结合健康体检,获得试验数据和初始研究队列,采集包括美国国立卫生院慢性前列腺炎症状指标(NIHCPSI)总评分、社会人口学资料、生活方式、用药手术史等基本信息。由经统一培训合格的专业人员为调查对象进行人体学参数测量,采集禁食8h的空腹静脉血标本,对PSA、甘油三酯、高密度脂蛋白胆固醇和空腹血糖等生化指标进行检测。对参与者行前列腺按摩取出前列腺液,利用玻片法计数前列腺液中白细胞的平均量,根据NIH-CPSI评分及有无炎症,分成Ⅳ型前列腺组与健康组。结果血清PSA水平在健康组和Ⅳ型前列腺炎组均值分别为0.91和1.27(ng/ml),标准差为0.79和1.52(ng/ml),差异有统计学意义(P<0.001)。年龄、甘油三酯、收缩压、舒张压、高血压、受教育程度、运动在Ⅳ型前列腺炎组大于健康组。Ⅳ型前列腺炎(WBC≥3+)对比健康组,随着PSA递增OR值也是递增的,分别是1.078、3.589、4.406。在PSAQ4中随着炎症的增加OR值也递增。分别加入年龄,教育水平、血脂异常、糖尿病、高血压、BMI、抽烟、饮酒、运动、舒张压、收缩压作为调整变量后Ⅳ型前列腺炎组及按白细胞分组Ⅳ型前列腺炎(WBC≥3+)随着PSA增加OR值逐渐递增。结论高水平的血清tPSA水平,是Ⅳ型前列腺炎的一个风险。Ⅳ型前列腺炎病人前列腺液中白细胞数量与血清PSA水平呈正相关。

Objective To investigate the relationship between asymptomatic inflammatory prostatitis （AIP）and serum prostate specific antigen （PSA）. Methods Data collection was conducted in the Medical Examination Centre of Fangchenggang First People＆#39;s Hospital.During the physical examination,trained physi-cians administered a standard questionnaire,basic data including National Institutes of Health Chronic Prostati-tis Symptom Index （NIH-CPSI）,demographic information （age,education,occupation,etc）,history of dis-ease,and lifestyle risk factors （smoking,alcohol consumption,and physical activity）,and health status were collected using a standardized questionnaire.A trained profession conducted the anthtopometric parameters measurements for the participants.8 h-fasting vein blood was drawn and then the biochemical indexes [PSA, triglyceride （TG）,high density cholesterol-cholesterol （HDL-C）,and fasting blood glucose]were meas-ured.The expressed prostatic secretions （EPS）were collected and then were smeared on a glass slide for counting the mean WBC count of EPS.According to the NIH-CPSI score,and presence of inflammation,the participants were divided into a NIH-IV prostatitis group and a healthy group. Results The mean value of serum PSA in the healthy group and the NIH-IV prostatitis group were 0.91 ng/ml and 1.27 ng/ml,the standard deviation was 0.79 ng/ml,and 1.52 ng/ml,there were statistically significant differences （P 〈0.001）.In NIH-IV prostatitis group,the scores of age,TG,diastolic blood pressure （DBP）,systolic blood pressure （SBP）,hypertension,education status,physical activity were higher than those in the healthy group. NIH-IV prostatitis （WBC≥3＋）group compared to healthy group,along with the elevated PSA the OR value was also increased,the OR value was 1.078,3.589,4.406,respectively.In PSAQ4,with the elevation of in-flammation the OR value also increased.Respectively in age,education status,dyslipidemia,diabetes,high blood pressure,BMI,smoking,drinking,physical activity,DBP and SBP as adjust variable,in NIH - IV＆amp;nbsp;prostatitis group and NIH-IV prostatitis （WBC≥3＋）group,as PSA increased the OR value increased gradu-ally. Conclusion High levels of serum PSA is a potential risk factors for NIH-IV asymptomatic inflamma-tory prostatitis.The EPS WBC counts in patients with NIH-IV prostatitis is positively associated with serum PSA.