肺结核高分辨率CT半定量评分与酶联免疫斑点形成细胞数的相关性分析

The correlation analysis between semi-quantitative score of high-resolution and spot forming cells in ELISPOT of patients with pulmonary tuberculosis

目的探讨肺结核高分辨率CT(HRCT)表现、半定量评分及其与酶联免疫斑点形成细胞数的相关性,为活动性肺结核临床诊断提供依据。方法①对203例临床诊断为肺结核患者进行HRCT检查和酶联免疫斑点形成细胞数分组检测。②对肺结核各组CT评分与酶联免疫斑点形成细胞数进行统计分析,比较各组间的相关性及有无差异。结果①一侧继发性肺结核组、两侧继发性肺结核组、结核性胸膜炎组及结核控制组HRCT评分分值与不同抗原的酶联免疫斑点形成细胞数检测值一致性较好。②血行播散性肺结核组HRCT评分与不同抗原的酶联免疫斑点形成细胞数检测值一致性较低。结论 HRCT评分分值中除血行播散性肺结核组外,其他各组评分分值与酶联免疫斑点形成细胞数的相关性较好,提示活动性结核病的可能性大。

Objective To study of HRCT findings of pulmonary tuberculosis, the relationship between CT findings with semi-quantitative score of pulmonary tuberculosis and enzyme-linked immunosorbent spot forming cell number, in order to provide proofs for pulmonary tuberculosis activity. Methods Two hundrend and three patients with pulmonary tuberculosis, who had HRCT and enzyme-linked immunospat assay, were enrolled in this study. Semi-quantitative score of CT finding were compared with enzyme-linked immanospat assay. Results There were well correction between CT findings and enazyme-linked immunospot observed in group of one side secondary pulmonary tuberculosis, two side secondary pulmonary tuberculosis, tuberculosis pleuritis and control group. The correction of hematogenous disseminated pulmonary tuberculosis was poor. Conclusion Except hematogenous disseminated pulmonary tuberculosis, semiquantitative score of CT findings can be used as a biomarker for pulmonary tuberculosis activity.