柴芍六君子汤对晚期原发性肝癌患者生活质量的影响

Effect of Chaishaoliujunzi Decoction on the Life Quality of Advanced Primary Hepatic Carcinoma Patients

目的:观察柴芍六君子汤对晚期原发性肝癌患者生活质量的影响。方法:将60例晚期原发性肝癌随机平均分成治疗组与对照组。对照组给予西药保肝对症支持疗法,治疗组在对照组的基础上加用柴芍六君子汤治疗。观察两组治疗后生活质量及临床症状改善和不良反应变化。结果:两组临床证候改善比较,治疗组与对照组总改善率分别为86.7%和63.3%(P<0.05);两组体质量与卡氏评分情况比较,体质量:治疗组治疗后比治疗前增加明显(P<0.05),对照组治疗前后比较,差异无显著性(P>0.05)。卡氏评分:治疗组治疗后比治疗前增加(P<0.05),且优于对照组(P<0.05);对照组治疗前后无变化。两组生活质量情况比较,食量增加:治疗组22例(73.3%),对照组14例(46.7%);睡眠改善:治疗组26例(86.7%),对照组16例(53.3%);治疗组优于对照组(P<0.05)。两组患者生存率比较,两组患者3个月、6个月、1 a生存率分别为90.0%、60.0%、40.0%和73.3%、36.7%、20.0%(P<0.05)。两组患者治疗过程中未见不良反应发生。结论:柴芍六君子汤治疗晚期原发性肝癌能减轻不良反应,改善生活质量,延长生存期。

Objective：To observe the effect of the Chaishaoliujunzi Decoction on the life quality of advanced primary hepatic carcinoma patients. Methods ：60 cases of advanced primary hepatic carcinoma were randomly divided into the treatment group and the control group with 30 cases in each group, both groups are performed with the same western medicine liver supportive therapy. The treatment group added Chaishaoliujunzi Decoction treatment. Two groups were observed after treatment on the quality of life and the improvement of clinical symptoms and adverse changes. Results：Both groups of clinical symptom improvement, compared with the treatment group and the control group,the total improvement rate were 86.7% and 63.3% （P 〈0.05） ;two groups of weight and Karnofsky score comparison： the treatment group of weight after treatment was increased than before treatment （ P 〈 0.05 ）, compared with the control group before and after treatment, no significant difference （ P 〉 0.05 ）. The treatment group of Karnofsky score after treatment was increased than before treatment （ P 〈 0.05 ）, and was better than the control group （ P 〈 0.05 ） ; the control group before and after treatment with no change. Two groups of life quality compared,intake increases：the treatment group of 22 cases （73.3 % ）, 14 cases in the control group （46.7%） ;and sleep improvement：the treatment group of 26 cases （86.7%）, 16 cases in the control group （53.3%） ;the treatment group was better than the control group（ P 〈 0. 05 ）. Two groups of patients survival rate between the two groups of patients,3 months ,6 months ,one year survival rates were 90% ,60% ,40% and 73.3% ,36.7% ,20% （ P 〈0.05 ）. There was no side effects in both groups of patients during the treatment. Conclusion ： Chaishaoliujunzi Decoction in the treatment of advanced primary hepatic carcinoma can reduce the adverse reaction.improve the living quality, and prolong the lifetime.