瑞舒伐他汀钙治疗颈动脉粥样硬化斑块的疗效观察

Clinical efficacy of rosuvastatin calcium in treatment of carotid atherosclerosis

目的观察瑞舒伐他汀钙治疗颈动脉粥样硬化斑块的疗效。方法将72例不同程度颈动脉粥样硬化斑块形成患者分成治疗组和对照组,对照组常规降糖、降压、饮食控制、服用阿司匹林肠溶片100mg,1次/d,治疗组在对照组治疗基础上服用瑞舒伐他汀钙10mg,每晚睡前1次,为期12个月。观察治疗前后血脂、颈动脉内膜中层厚度(IMT)、斑块面积、斑块总个数变化。结果治疗组治疗12个月后血清总胆固醇(TC)、血清甘油三酯(TG)、血清低密度脂蛋白胆固醇(LDL-C)水平下降,IMT值、斑块面积减小,与治疗前比较,差异有统计学意义(P<0.05),而血清高密度脂蛋白胆固醇(HDL-C)水平、斑块总个数变化不大(P>0.05)。结论瑞舒伐他汀钙是治疗颈动脉粥样硬化较好的选择,不但可以降低血脂水平,还能降低斑块面积,值得推广应用。

Objective To observe the effects of rosuvastatin calcium on treating carotid artery arteriosclerosis plaque. Methods All 72 patients with carotid artery arteriosclerosis plaque were divided into the treatment group（40 cases）and control group（32 cases）. The patients in control group were given drugs accordingly to decrease blood pressure, glucose and were given diet, and even enteric-coated aspirin 100 mg/d. On the basis of the same treatment for the control group, the patients in treatment group were given rosuvastatin calcium 10 mg/d. Lipid levels, total numbers and area of carotid artery plaque and intima-media thickness （IMT）was observed before treatment and 12 months after treatment and compared between two groups . Results After treatment, the serum total cholesterol（TC）, serum triglyceride（TG）, serum low-density lipoprotein（LDL-C） levels decreased, IMT, plaque area decreased,compared with pre-treatment and the control group（P〈0.05）. Serum high-density lipoprotein（HDL-C） levels and total numbers of carotid artery plaque were not of difference compared with pretreatment and the control group （P〈0.05）. Conclusion Rosuvastatin calcium can relieve atherosclerosis obviously, reduce plaque area and regulate blood lipid. It should be introduced.