针刺配合药物对非痴呆型血管性认知功能障碍的影响

Effect of Acupuncture plus Medication on Vascular Cognitive Impairment No Dementia

目的观察针刺配合奥拉西坦治疗非痴呆型血管性认知功能障碍(VCIND)的临床疗效。方法将66例VCIND患者随机分为治疗组和对照组,每组33例。治疗组采用针刺配合口服奥拉西坦治疗,对照组采用单纯口服奥拉西坦治疗,疗程为4星期。观测两组治疗前后简易精神状态评价量表(MMSE)、蒙特利尔认知评估量表(MoCA)及血浆同型半胱氨酸(Hcy)变化。结果两组治疗后MMSE、MoCA评分与同组治疗前比较,差异均具有统计学意义(P<0.01)。治疗组治疗后MMSE、MoCA评分与对照组比较,差异均具有统计学意义(P<0.05)。两组治疗后血浆Hcy含量与同组治疗前比较,差异均有统计学意义(P<0.01)。治疗组治疗后血浆Hcy含量与对照组比较,差异均具有统计学意义(P<0.05)。结论针刺配合口服奥拉西坦是一种治疗VCIND的有效方法。

Objective To observe the clinical efficacy of acupuncture plus Oxiracetam in treating vascular cognitive impairment, no dementia （VC1ND）. Method Sixty-six VCIND patients were randomized into a treatment group and a control group, 33 in each group. The treatment group was intervened by acupuncture plus oral administration of Oxiracetam, while the control group was only by Oxiracetam, for 4-week treatments in total. The Mini-mental State Examination （MMSE）, Montreal Cognitive Assessment （MoCA）, and plasma homocysteine （Hcy） were evaluated before and after treatment. Result After treatment, the MMSE and MoCA scores were changed significantly in both groups （P〈0.01）. After treatment, there were significant differences in comparing the MMSE and MoCA scores between the two groups （P〈0.05）. The plasma Hcy contents were changed significantly in the two groups after treatment （P〈0.01）. After treatment, there was a significant difference in comparing the Hcy content between the two groups （P〈0.05）. Conclusion Acupuncture plus Oxiracetam is an effective method in treating VCIND.