成年病人万古霉素治疗药物监测软件的研发

Development of Therapeutic Drug Monitoring Software of Vancomycin for Adult Patients

目的研制开发成年病人的万古霉素治疗药物监测软件,帮助临床进行万古霉素个体化用药。方法系统地检索PubMed数据库中发表于2012年9月前的文献,提取成年病人万古霉素群体药动学模型并结合笔者建立的模型构建万古霉素治疗药物监测模型集。根据建立的群体药动学模型和Bayesian原理,在Microsoft Visual Studio 2005集成开发环境中采用C++语言研发治疗药物监测软件。结果构建的治疗药物监测模型集包含14个群体药动学模型。基于模型开发的软件可根据病人信息的多寡分别进行群体、亚群体和个体预测,为临床万古霉素个体化给药提供帮助。结论本实验研发的软件涵盖了当前报道的万古霉素药动学模型,医生可以根据病人的实际情况选择适当的模型,具有较广的适用性。

OBJECTIVE To develop a therapeutic drug monitoring software of vancomycin for adult patients to help physician for personalized use of vancomycin. METHODS A system literature retrieval search was conducted in the PubMed database to collect the population pharmacokinetic studies published before September 2012. A set of therapeutic drug monitoring models for vancomycin was assembled by the models included in the above literatures and the model developed by the authors. Based on the Bayesian principle,a therapeutic drug monitoring software built upon these population pharmacokinetic models was developed with C ＋ ＋ in the integrated development environment（ Microsoft Visual Studio 2005）. RESULTS The set of therapeutic drug monitoring models included 14 population pharmacokinetic analyses. The software developed on these pharmacokinetic models could be applied to conduct population,subpopulation and individual predictions,thus help clinician in their individualized treatments. CONCLUSION This study developed software covers the current reported vancomycin pharmacokinetic model. Clinician can choose the appropriate model according to the actual situation of the patients.