氟比洛芬酯和帕瑞昔布钠用于玻璃体切割术的超前镇痛效果被引量：1

Preemptive Analgesic Effects of Flurbiprofen and Parecoxib in Vitrectomy

导出

摘要目的比较氟比洛芬酯和帕瑞昔布钠用于玻璃体切割术超前镇痛的效果。方法 75例择期在监测麻醉下行玻璃体切割术患者,随机分为对照组、氟比洛芬酯组和帕瑞昔布钠组。记录患者术后24 h内VAS评分及恶心呕吐的发生情况。结果 1,3,6 h氟比洛芬酯组和帕瑞昔布钠组的VAS评分均低于对照组(P<0.05),3组患者恶心呕吐发生率无明显差异。结论氟比洛芬酯和帕瑞昔布钠镇痛效果良好,不良反应少,能提供良好的术中及术后镇痛效果。 OBJECTIVE To compare the preemptive analgesic effects of flurbiprofen and parecoxib in vitrectomy. METHODS Seventy-five patients undergoing monitored anaesthesia care were randomly divided into 3 groups： control group,flurbiprofen group and parecoxib group. The visual analogue scale （VAS） and postoperative nausea and vomiting （PONV） were recorded within 24 h. RESULTS Compared with control group, VAS scores were significantly lower in flurbiprofen group and parecoxib group at 1, 3, 6 h（P〈0.05）. There were no significant differences among three groups in the incidence of PONV. CONCLUSION Flurbiprofen and parecoxib can offer more effective and safer analgesia for perioperative pain relief than saline in vitrectomy.

作者袁治国刘燃陈晓光

机构地区中国医科大学附属第一医院麻醉科

出处《中国现代应用药学》 CAS CSCD 2014年第5期583-586,共4页 Chinese Journal of Modern Applied Pharmacy

关键词氟比洛芬酯帕瑞昔布钠超前镇痛玻璃体切割术 flurbiprofen parecoxib preemptive analgesic vitretomy

分类号 R969.4 [医药卫生—药理学] R971.2 [医药卫生—药品]

引文网络
相关文献

参考文献9

1KATZ J.Pre-emptive analgesia:evidence,current status and future directions [J].Eur J Anaesthesiol Suppl,1993(10):8-13.
2ELSEIFY Z A,EL-KHATTAB S O,KHATTAB A M,et al.Combined parecoxib and I.V.paracetamol provides additional analgesic effect with better postoperative satisfaction in patients undergoing anterior cruciate ligament reconstruction[J].Saudi J Anaesth,2011,5(1):45-49.
3ARDOIN S P,SUNDY J S.Update on nonsteriodal anti-inflammatory drugs [J].Curr Opin Rheumatol,2006,18(3):221-226.
4SWIFT J Q,GARRY M G,ROSZKOWSKI M T,et al.Effect of flurbiprofen on tissue levels of immunoreactive bradykinin and acute postoperative pain [J].J Oral Maxillofac Surg,1993,51(2):112-116.
5ESME H,KESLI R,APILIOGULLARI B,et al.Effects of flurbiprofen on CRP,TNF-ct,IL-6,and postoperative pain of thoracotomy [J].Int J Med Sci,2011,8(3):216-221.
6BAJAJ P,BALLARY C C,DONGRE N A,et al.Role of parecoxib in pre-emptive analgesia:comparison of the efficacy and safety of pre-and postoperative parecoxib in patientsundergoing general surgery [J].J Indian Med Assoc,2004,102(5):272-278.
7RATCHANON S,PHALOPRAKAM C,TRAIPAK K.Pain control in laparoscopic gynecologic surgery with/without preoperative(preemptive)parecoxib sodium injection:a randomized study [J].J Med Assoc Thai,2011,94(10):1164-1168.
8OHMUKAI O.Lipo-NSAID preparation [J].Adu Drug Delivery Rev,1996,20(3):203-207.
9SCHUG S A,JOSHI G P,CAMU F,et al.Cardiovascular safety of the cyclooxygenase-2 selective inhibitors parecoxib and valdecoxib in the postoperative setting:an analysis of integrated data [J].Anesth Analg,2009,108(1):299-307.